نتایج جستجو برای: leukocyte antigen

تعداد نتایج: 225025  

Journal: :International Journal of Immunogenetics 2021

Abstract MHC class I (MHC‐I) molecules undergo an intricate folding process in order to pick up antigenic peptide present the immune system. In recent years, discovery of a new editor for MHC‐I has added extra level complexity our understanding how presentation is regulated. On top this, incredible diversity leads significant variation interaction between and components antigen processing pathw...

Journal: :The Journal of clinical investigation 1966
P Lalezari G E Bernard

Development of methods for detection of leukocyte antigens has made possible the classification of human leukocytes into different antigenic types, distinct from those of erythrocytes. To date several such antigen systems have been described (1-4). Studies on the distribution of some of these antigens in various blood cells have indicated that they are present in both granulocytic and nongranul...

Journal: :Transplantation 2014
Charles T Lutz Ahmad Al-Attar John R May C Darrell Jennings

BACKGROUND Alloantibodies to the Bw4 epitope are known to be heterogeneous, but it is widely assumed that anti-Bw4 alloantibodies arise only in individuals who do not express a Bw4 epitope. METHODS Bw4 expression was confirmed by DNA sequence analysis. Anti-Bw4 reactivity was confirmed by absorption with transfected cells. RESULTS A Bw4 (B*27:05 or B*27:13) patient expressed antibody that b...

2007
Noora Alakulppi Jarmo Laine Jukka Partanen

........................................................................................ 9 INTRODUCTION ................................................................................. 11 REVIEW OF THE LITERATURE .............................................................. 12 1 KIDNEY TRANSPLANTATION .............................................................. 12 1.1 General aspects of kid...

Journal: :Iranian journal of kidney diseases 2012
Faris Q Alenzi Mohamed L Salem Fawwaz A Alenazi Richard K Wyse

Goodpasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic autoantibodies that react with the components of the glomerular basement membrane. The clinical condition of the Goodpasture syndrome is characterized by an acute necrotizing glomerulonephritis, often with accompanying pulmonary hemorrhage. Notably, the Goodpasture antigen has been localized t...

Journal: :Infection and immunity 1972
C Ushimi J B Henson J R Gorham

Primary horse leukocyte cultures were inoculated with 2 or 10 50% tissue culture infective doses (TCID(50)) of equine infectious anemia (EIA) virus per cell, and the titer of cell-associated and fluid-phase virus was determined from 1 to 72 hr postinoculation (PI). Cover slips were collected from 4 to 72 hr PI and stained for EIA viral antigen by the indirect immunofluorescent (FA) technique. V...

Journal: :PLoS Genetics 2007
Eric Spierings Matthijs Hendriks Léna Absi Angelica Canossi Sonal Chhaya John Crowley Harry Dolstra Jean-François Eliaou Tom Ellis Jürgen Enczmann Maria E Fasano Thibaut Gervais Clara Gorodezky Brigitte Kircher David Laurin Mary S Leffell Pascale Loiseau Mari Malkki Miroslaw Markiewicz Miryam Martinetti Etsuko Maruya Narinder Mehra Fatma Oguz Machteld Oudshoorn Noemi Pereira Rajni Rani Ruhena Sergeant Jackie Thomson Thuong Hien Tran Hannu Turpeinen Kuo-Liang Yang Renata Zunec Mary Carrington Peter de Knijff Els Goulmy

Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled ...

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