BACKGROUND Formulation of a medical preparedness plan for treating severely bleeding casualties during naval deployment is a significant challenge because of territory covered during most missions. The aim of this study was to evaluate the concept of "walking blood bank" as a supportable plan for supplying safe blood and blood products. METHODS In 2013, the Royal Norwegian Navy conducted anti...

From a semantic viewpoint, it is obvious that “red cell concentrates” should contain red cells only, and the same is true for platelet concentrates—they should contain platelets and no other cells (e.g., contaminating leukocytes). Viable donor leukocytes contaminate blood components and are linked to a wide variety of acute and long-term transfusion complications, including febrile transfusion ...

Összefoglaló. A vérkészítmény-irradiáció célja a transzfúzió-asszociált graft-versus-host betegség (TA-GVHD) megelőzése magvas sejtek nukleinsav-állományának szelektív károsításával. Az irradiáció hátránya káliumtartalom növekedése, az általános sejtkárosító hatás, körülményesebb előállítással járó időveszteség és többletköltség. legújabb nemzetközi ajánlásokban utóbbi évtizedek szisztematikus ...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. The impact of perioperative blood transfusion (BT) on survival outcomes has been reported in several urological and non-urological surgeries (1,2). Considering bladder cancer (BCa) patients, radical cystectomy (RC) with bilateral pelvic lymph node dissection represents the standard of care in muscle invasive and recur...

INTRODUCTION For many years, platelet concentrates have been used for the prevention as well as treatment of bleeding disorders, especially in those patients with haematological problems involving platelet disorders as well as refractoriness, In addition, platelet concentrates (PCs) have been widely used to support patients undergoing bone marrow transplantation or who are receiving myelotoxic ...

BACKGROUND Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease caused by infection with the agent of bovine spongiform encephalopathy. After the recognition of vCJD in the UK in 1996, many nations implemented policies intended to reduce the hypothetical risk of transfusion transmission of vCJD. This was despite the fact that no cases of transfusion transmission had yet been identi...

Transfusion-transmitted cytomegalovirus (TT-CMV) infection can lead to significant morbidity and mortality in CMV-negative (CMV-N) hematopoietic progenitor cell (HPC) transplant patients. In 1995, Bowden and colleagues demonstrated the efficacy of leukoreduced components to reduce TT-CMV in most high-risk populations, although there remained safety concerns in CMV-N allogeneic HPC transplant re...

Engineered red blood cells (RBCs) expressing viral receptors could be used therapeutically as traps, RBCs lack nuclei and other organelles required for replication. However, expression of on is difficult to achieve since mature erythrocytes the cellular machinery synthesize proteins. Herein, we show that combination a powerful erythroid-specific system transgene codon optimization yields high l...