Finite-time boundedness and H∞ finite-time boundedness of switched linear systems with time-varying delay and exogenous disturbances are addressed. Based on average dwell time (ADT) and free-weight matrix technologies, sufficient conditions which can ensure finite-time boundedness and H∞ finite-time boundedness are given. And then in virtue of the results on finite-time boundedness, the state m...

In this paper we extend the notion of convergent systems defined by B.P. Demidovich and introduce the notions of uniformly, exponentially convergent and input-to-state convergent systems. Basic (interconnection) properties of such systems are established. Sufficient conditions for input-to-state convergence are presented. For a class of nonlinear systems we design (output) feedback controllers ...

Hormone therapy is well established for treating patients with prostate cancer and remains the mainstay of the treatment of metastatic and locally advanced disease, this article reviews the rationale for its use, its different forms, and complications and controversies still surrounding some of its modalities. Availability of long-acting synthetic luteinizing hormone-releasing hormone (LHRH) ag...

We describe the case of a 6.5-year-old girl with central precocious puberty (CPP), which signifies the onset of secondary sexual characteristics before the age of eight in females and the age of nine in males as a result of stimulation of the hypothalamic-pituitary-gonadal axis. Her case is likely related to her adoption, as children who are adopted internationally have much higher rates of CPP...

BACKGROUND Doxycycline (Dox) has a number of non-antibiotic properties. One of them is the inhibition of matrix metalloproteinase (MMP) activity. The aim of this study was to assess the effects of Dox in a rat endometriosis model. METHODS Endometriosis was surgically induced in 40 rats by transplanting of endometrial tissue. After 3 weeks, repeat laparotomies were performed to check the impla...

PURPOSE To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT. MATERIALS AND METHODS This prospective analysis included male sex offenders who voluntarily received leuprolide acetate in order to alleviate sexua...

Received February 5, 2013, Revised March 30, 2013, Accepted for publication April 15, 2013 Corresponding author: Young Min Park, Department of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Banpo 4 dong, Seochogu, Seoul 137-701, Korea. Tel: 82-2-2258-6223, Fax: 82-2-5999950, E-mail: [email protected] This is an Open Access ...

The established agent leuprorelin acetate can be administered in combination with a novel biodegradable polymer matrix (Atrigel delivery system) to reduce testosterone levels in men with advanced hormone-dependent prostate cancer. Since 2007, this new formulation is available as a 6-month depot (Eligard 45 mg). The results of a recent non-interventional study, investigating the efficacy and saf...

Methods. This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5-15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback. Forty-nine females <9 years old with Tanner breast stage ≥2 before 8 years and 6 males <10 years old with Tanner genital stage ≥2 before 9 years with stimulated LH ≥10 IU/L and bone age adv...