STUDY QUESTION What are the regression and hysterectomy rates for women treated with the levonorgestrel-releasing intrauterine system (LNG-IUS) compared with oral progestogens for endometrial hyperplasia (EH)? SUMMARY ANSWER The LNG-IUS achieves higher regression and lower hysterectomy rates than oral progestogens in the treatment of complex and atypical hyperplasia. WHAT IS KNOWN ALREADY T...

Most combination OCPs contain ethinyl estradiol (20 to 50 mcg) and a synthetic progestin (e.g., norgestrel, norethindrone, levonorgestrel, desogestrel). These pills inhibit ovulation in most women. They also induce thickening of the cervical mucus, which impedes transport of sperm to the uterus. With perfect use, only 0.1 percent of women become pregnant within the first year of using a combina...

The levonorgestrel-releasing intrauterine system (LNG-IUS), originally designed for contraception, has since been applied to various gynecologic diseases. This article summarizes the current status of clinical applications of LNG-IUS to the treatment of gynecologic diseases such as heavy menstrual bleeding, endometriosis, leiomyoma, adenomyosis, endometrial hyperplasia, and early-stage endometr...

720 CMAJ, July 14, 2015, 187(10) ©2015 8872147 Canada Inc. or its licensors Right now, a woman turned away from her pharmacist has only one option for emergency contraception: getting a copper IUD inserted into her uterus by a physician. Copper IUDs are more than 99% effective at preventing pregnancy, but they can be expensive (up to several hundred dollars) and finding a doctor to insert the d...

Epidemiologic, laboratory, and animal evidence suggests that progestins and vitamin D may be potent ovarian cancer preventives. Our objectives were to evaluate progestins as reproductive tract cancer chemopreventives in the chicken, determine whether restricted ovulation affected the incidence of reproductive tract tumors, and assess whether vitamin D would confer cancer protection either alone...

Objective: Our aim was to investigate the effects of levonorgestrel-releasing intrauterine system on the endometrium of ovariectomized rats under estrogen replacement therapy. Methods: Twenty-four Sprague-Dawley rats were divided into four groups and operated for the insertion of levonorgestrelreleasing (3 μg/day) or placebo-bearing intrauterine devices (IUD). Following the operation, the rats ...

OBJECTIVE To investigate if continuation rates in first-time users of oral hormonal contraceptives differed between different formulations and to measure if the rates were related to the prescribing categories, that is, physicians and midwives. DESIGN A longitudinal national population-based registry study. SETTING The Swedish prescribed drug register. PARTICIPANTS All women born between ...

OBJECTIVE To assess the risk of venous thrombosis in current users of non-oral hormonal contraception. DESIGN Historical national registry based cohort study. SETTING Four national registries in Denmark. PARTICIPANTS All Danish non-pregnant women aged 15-49 (n=1,626,158), free of previous thrombotic disease or cancer, were followed from 2001 to 2010. MAIN OUTCOME MEASURES Incidence rate...