The aim of this study was to evaluate the effects of lactoferrin (LF) on the growth of fibroblasts derived from nasal polyps. We showed that the proliferation of fibroblasts was inhibited in a dose-dependent manner by both native and recombinant LF. The greatest inhibition of proliferation was caused by human milk-derived, iron-saturated LF. The inhibition of fibroblast proliferation was not sp...

We assessed the potential of lactoferrin (LF), a multifunctional milk protein, for treatment of oral candidiasis with immunosuppressed mice, which have local symptoms characteristic of oral thrush. Oral administration of bovine LF in drinking water starting 1 day before the infection significantly reduced the number of Candida albicans in the oral cavity and the score of lesions on the tongue o...

w: LF (nu) 67-9 (11 1)* 53-2 (7 3) HF (nu) 32-1 (8 1)* 42-7 (4 9) LF/HF 2-33 (0 88)* 1-28 (0-21) Stage 2 non-REM sleep: LF (nu) 39-9 (13-9) 36-2 (15-5) HF (nu) 60-1 (15-2) 57.3 (11-2) LF/HF 0-84 (0 63) 0-76 (0 48) Stage 3-4 non-REM sleep: LF (nu) 26-9 (11 1) 25-9 (8-6) HF (nu) 73-1 (14 6) 66-2 (11-6) LF/HF 0 47 (0 41) 0-46 (0-32) REM sleep: LF (nu) 56-3 (12 8) 53 2 (16-6) HF (nu) 43 7 (8 3) 41 ...

The ongoing chronic inflammation and subsequent fibrosis play an important role in ligamentum flavum (LF) fibrosis and hypertrophy in patients with lumbar spinal canal stenosis (LSCS). Leptin is a chronic inflammatory mediator and involved in the fibrotic process in multiple organ systems. The present study aimed to investigate the role of leptin in LF fibrosis and its related regulatory mechan...

Lactoferrin (Lf) expression was determined immunohistochemically in 57 formalin-fixed paraffin-embedded bioptic samples obtained from an equal number of patients treated by surgery to remove pigmented skin lesions (nevi = 23; melanoma = 12; vulgaris and seborrhoeic warts = 12; basal cell carcinoma = 10); in addition, 10 specimens of normal skin were studied as control. On 3 mm thick sections, d...

In recent years, microstrip antennas have become a popular research subject with the increasing use of mobile technologies. With development neural networks, design and analysis are carried out quickly high accuracy. However, optimizing weight matrices bias vectors deep learning models is an important challenge for engineering problems. This study presents network-based (DNN-based) model to est...

Entamoeba histolytica is a human parasite that requires iron (Fe) for its metabolic function and virulence. Bovine lactoferrin (B-Lf) and its peptides can be found in the digestive tract after dairy products are ingested. The aim of this study was to compare virulent trophozoites recently isolated from hamster liver abscesses with nonvirulent trophozoites maintained for more than 30 years in cu...

The aim of this study was to determine the therapeutic efficacy of lactoferrin (Lf) on dextran sulphate sodium (DSS)‑induced experimental colitis in BALB/c mice. Eighty BALB/c mice were randomly divided into 4 groups; the normal, model, apo‑Lf and holo‑Lf groups. Fecal character, fecal occult blood, hematochezia and disease activity index (DAI) were recorded daily. The length of the colon was m...

In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal toxin. PrAgU2/LF was cytotoxic to five out of nine AML cell lines. Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK a...

Lactoferrin (Lf) is an iron-binding protein found in high concentrations in mammary secretions but synthesized by many tissues. Bovine mammary tissue secretes μg/ml mass of Lf in milk, but during involution and prepartum periods, 20–80 mg/ml concentrations may be observed. While a number of functions have been ascribed to lactoferrin, only the antimicrobial and lymphocyte interactions have comp...