Severe drug-induced liver injury (DILI) remains a major safety issue due to its frequency of occurrence, idiosyncratic nature, poor prognosis, and diverse underlying mechanisms. Numerous experimental approaches have been published to improve human DILI prediction with modest success. A retrospective analysis of 125 drugs (70 = most-DILI, 55 = no-DILI) from the Food and Drug Administration Liver...

Financial markets are exposed to systemic risk (SR), the risk that a major fraction of the system ceases to function, and collapses. It has recently become possible to quantify SR in terms of underlying financial networks where nodes represent financial institutions, and links capture the size and maturity of assets (loans), liabilities, and other obligations, such as derivatives. We demonstrat...

This paper studies the effects of financial integration on economic growth using an international panel data of 83 countries from 1974-2007. The effects of financial integration on economic growth differ considerably, depending on the type of external assets and liabilities as well as on the characteristics of countries that experience financial integration. In particular, when we break down ex...

The extension of the theory of life contingencies to a stochastic interest environment and its application to solvency valuation are discussed. Although life contingencies are widely used in traditional actuarial valuations of life insurance contracts, certain complications arise in a stochastic interest environment that are not evident when using traditional deterministic interest assumptions....

Abstract Marxists see firm ownership as an instrument for capitalists to exploit workers for “surplus value”. Neo-classical economists treat capital and labour equally as factors of production, which generate wages for workers and profits for capital owners. Both “Surplus value” and profits should be, and indeed are, on average, positive in typical market economies. This paper proposes a theory...

Joint mapping for multiple quantitative traits has shed new light on genetic mapping by pinpointing pleiotropic effects and close linkage. Joint mapping also can improve statistical power of QTL detection. However, such a joint mapping procedure has not been available for discrete traits. Most disease resistance traits are measured as one or more discrete characters. These discrete characters a...

Despite the e ort made to de ne methods for the design of high quality software, experience shows that failures of IT systems due to software errors remain very common and one must admit that even critical systems are not immune from that type of errors. One of the reasons for this situation is that software requirements are generally hard to elicit precisely and it is often impossible to predi...

The term “imbalances” is often used to describe situations in which some economic units accumulate large volumes of liabilities. The economic units could be within domestic sectors (household, business, and government sectors)—in which case we refer to them as domestic imbalances—or different countries—in which case we refer to them as global imbalances. An example of domestic imbalance is the ...

This study concerns large margin nearest neighbors classifier and its multi-metric extension as the efficient approaches for metric learning which aimed to learn an appropriate distance/similarity function for considered case studies. In recent years, many studies in data mining and pattern recognition have demonstrated that a learned metric can significantly improve the performance in classifi...