A post hoc analysis was performed using combined data from two Phase I tolerability/immunogenicity studies of monovalent human papillomavirus type 11 (HPV11) or HPV16 L1 virus-like particle (VLP) vaccines. The goal was to determine if the HPV16 L1 VLP vaccine protected against HPV16 infection. Vaccine or placebo was given at 0, 2 and 6 months. HPV16 infection was defined by positive polymerase ...

There are four forms of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) found in nature. Forms I, II, and III catalyse the carboxylation and oxygenation of ribulose 1,5-bisphosphate, while form IV, also called the Rubisco-like protein (RLP), does not catalyse either of these reactions. There appear to be six different clades of RLP. Although related to bona fide Rubisco proteins at th...

Having children or not is one of the most important decisions that a person will make in his or her lifetime. The Reproductive Life Plan (RLP) is a protocol that aims to encourage both women and men to reflect on their reproductive intentions and to find strategies for successful family planning, for example to have the wanted number of children and to avoid unwanted pregnancies as well as ill-...

Vaccination is the most effective means for the prevention of influenza, including pandemic strains. An ideal pandemic influenza vaccine should provide effective protection with the fewest number of doses in the shortest amount of time, and among the greatest proportion of the population. The current manufacturing processes required for embryonated chicken-egg-based influenza vaccines are limit...

ABSTRACT In continuation of our model of composite electron, its companion neutrinos, photon and electro-weak gauge bosons as well as their super-partners based on extended Lorentz group SU(3)⊗SU(3) in (8+1) dimensional space-time, we show that the remaining leptons, quarks, lepto-quarks and gluons as well as their respective super-partners can be considered as composites of fundamental particl...

We assume that a single particle of mass m cannot be localized to better than +h/2mc. Using our understanding of finite and discrete measurement accuracy, the single particle transition in 1+1 space-time from (O, O) to (z, t) can then be characterized by a scale factor N and two integers r, 1defined by z = N(r – l)h/mc and ct = N(r + l)h/mc 2. The average velocity over this finite interval is v...

The incorporation of multiple antigens into a single human papillomavirus (HPV) vaccine may induce immune interference. To evaluate whether interference occurs when HPV type 16 (HPV16) virus-like particles are combined in a multivalent vaccine, we conducted a study to evaluate anti-HPV16 responses among subjects receiving three-dose regimens of either a monovalent HPV16 vaccine or a quadrivalen...

In CDMA cellular networks, the soft handoff technique allows a mobile host to communicate with multiple base stations simultaneously, improving the transmission quality of the wireless channel and avoiding disconnection upon to base station switching. In this paper, we evaluate the influence of soft handoff on TCP (Transport Control Protocol) throughput in CDMA cellular networks through simulat...

Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein derived from multiple HPV types induces lower titer, but more broadly neutralizing and protective...

We describe the influence of microgel packing on colloidal-phase mediated heteroaggregation using poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide) microgels with 1% mol or 5% mol N,N'-methylenebis(acrylamide) cross-linker. This system is uniquely designed to interrogate the influence of microgel structure and stiffness on microgel deformation at a curved interface by elminating t...