Understanding the important role of non-specific immune response in protecting body against development numerous diseases has become partially possible after discovery several classes pattern recognition receptors (PRR), such as Toll-like or NOD-like receptors. A group cytoplasmic proteins called inflammasome, which detect PAMP and DAMP through PRR receptors, is able to activate pro-inflammator...

when grown in monolayer culture at low density and with the addition of serum, cartilage cells dedifferentiate or are overgrown by fibroblast-like cells. the aim of this study was to optimize the cultivation of chondrocytes in monolayer culture and to slow down their transformation or their overgrowth by fibroblast-like cells. the interaction between chondrocytes and cartilage-specifc matrix is...