Adolescent substance abuse is a major public health concern. It is associated with an increased incidence of various psychiatric disorders like depressive disorders, anxiety disorders, attention deficit hyperactivity disorder, and conduct disorders and the relationship between mental and behavioral disorders and the substance use problems seems to be bi-directional. Adolescent suicide and subst...

Prostaglandins sensitize sensory neurons to activation by mechanical, thermal and chemical stimuli. This sensitization also results in an increase in the stimulus-evoked release of the neuroactive peptides, substance P and calcitonin gene-related peptide from sensory neurons. The cellular transduction cascade underlying the prostaglandin-induced augmentation of peptide release is not known. The...

The avian ciliary ganglion receives its only recognized input from the nucleus of Edinger-Westphal. This is known to be a cholinergic input. In the present study, using fluorescein isothiocyanate and peroxidase-antiperoxidase immunohistochemical methods, substance P-like and enkephalin-like immunoreactivity has been found within preganglionic terminals of the avian ciliary ganglion. The ciliary...

1. Plasma prorenin (inactive renin), which accounts for about 70% of the total renin in human plasma, was almost completely separated from active renin by affinity chromatography on Cibacron blue F3G-A-agarose. The slight residual renin activity present in the prorenin peak can be removed on concanavalin A-Sepharose, demonstrating that prorenin is completely inactive. 2. The renin activity of b...

Digoxin was measured by radioimmunoassay in the plasma of 25 patients with aneurysmal subarachnoid haemorrhage who had not received digoxin treatment. After heating the plasma an endogenous substance cross reacting with antibodies to digoxin was identified in 18 cases. The presence of this substance was significantly related to the total amount of blood and to the presence of blood in the front...

Summiary. Immature (8-mmii11), miie(liumiii mature (1l-mm), andI muature green (16an1d 17-mm1ni) )ean seeds (Phlaseolis zvitlgaris L. cv. Ken,tucl-y \Wonder andl Bountiful) were incubated in gil,bberellin A1 soluitionis for 24 lhours at 200. Extracts from the seeds were separated ilnto nionacidic, acidic ethyl acetate, and acidic butalnol fractionis. These were chromatographed. The eluates of t...

Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the antiserum with 10 micro M synthetic SP. Specific SP-like immunoreactivity was ...

In the previous papers (Ito and Higashi, 1961; Higashi, 1961), it was reported that a protein which stimulates the increase of the number and size of the fatty granules in the crop milk of pigeons was obtained from human placenta by the fractional precipitation with ammonium sulfate. The present communication describes the procedure of purification of this biologically active substance and some...