Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization. Currently, the causes of NE rupture are unclear. Here, we show that NE rupture in cancer cells relies on the assembly of contractile actin bundles that interact with the nucleus via the linker of nucleoskeleton and cytosk...

The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome movements. Recent studies have shed light on...

Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH)-peptide bearing proteins residing in the oute...

Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery and functional annotation of Linc-YY1, a novel lincRNA originating from the promoter of the transcription factor (TF) Yin Yang 1 (YY1). Starting from whole transcriptome shotgun sequencing (a.k.a. RNA-seq) data from muscle C2C12 cells, a series of bioinformatics analysis was applied towards the iden...

This paper gives an overview of a prototype implementation of a fragment of the logic Linc [5, 8, 13] (also referred to as FOλ∆∇ in [5]), which we tentatively call ‘Level 0/1 Prover’ here. This implementation is part of a larger project, Parsifal, at INRIA Futurs (see http://www.lix.polytechnique.fr/~dale/parsifal). The logic Linc is an extension of first-order intuitionistic logic with a proof...

Crisis in neuroimaging: is neuroimaging failing 15 years after the decade of the brain? André Zugman, João R. Sato, Andrea P. Jackowski Laboratório Interdisciplinar de Neurociências Clı́nicas (LiNC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP Brazil. Centro de Matemática, Computação e Cognição, Universidade Federal do ABC (UFABC), Santo André, SP, Bra...

We have read with a great interest the excellent article by Pasch et al. (2015) which describes the role of Sun4 in sperm head formation and fertility. The authors have used a Sun4 knockout (Sun4) mouse model to study the function of Sun4 in spermatogenesis. They observed that homozygous Sun4 males are infertile and present a globozoospermia-like phenotype. Further, they demonstrate that Sun4 i...

The election of 1860 was one of the most important and contentious elections in US history. It was also one of the most interesting. Four candidates from three different parties battled for the presidency and all four received a significant number of votes. We ask whether Lincoln’s victory was sound, or was it due to a fluke in the electoral system? Did a Lincoln win plausibly represent the wil...