Understanding the role of genetic variation in human diseases remains an important problem to be solved in genomics. An important component of such variation consist of variations at single sites in DNA, or single nucleotide polymorphisms (SNPs). Typically, the problem of associating particular SNPs to phenotypes has been confounded by hidden factors such as the presence of population structure...

Linear mixed models (LMMs) provide a still underused methodological perspective on combining experimental and individual-differences research. Here we illustrate this approach with two-rectangle cueing in visual attention (Egly et al., 1994). We replicated previous experimental cue-validity effects relating to a spatial shift of attention within an object (spatial effect), to attention switch b...

The mixed logit model is considered to be the most promising state of the art discrete choice model currently available. Increasingly researchers and practitioners are estimating mixed logit models of various degrees of sophistication with mixtures of revealed preference and stated preference data. It is timely to review progress in model estimation since the learning curve is steep and the unw...

Recent studies show that soil animal count data are characterized by the presence of excess zeros and overdispersion, which violate the assumptions of standard statistical tests. Despite this, analyses have consisted of mainly non-parametric tests and log-normal least square regression (i.e. ANOVA). Failure to accommodate zero inflation in count data can result in biased estimation of ecologica...

A typical task in statistical genetics is to find a sparse linear relation between genotypes with phenotypes, but often the data are confounded by age, ethnicity or population structure. We generalize the linear mixed model (LMM) Lasso approach for feature selection under confounding to the case of binary labels. This case is much more involved, as marginalization over the correlated noise lead...

The mixed logit model is considered to be the most promising state of the art discrete choice model currently available. Increasingly researchers and practitioners are estimating mixed logit models of various degrees of sophistication with mixtures of revealed preference and stated choice data. It is timely to review progress in model estimation since the learning curve is steep and the unwary ...

The spectral unmixing of a linear mixture model (LMM) with Normalized Difference Vegetation Index (NDVI) constraints was performed to estimate the fraction of vegetation cover (FVC) over the earth’s surface in an effort to facilitate long-term surface vegetation monitoring using a set of environmental satellites. Although the integrated use of multiple sensors improves the spatial and temporal ...

Estimation of heritability is fundamental in genetic studies. Recently, heritability estimation using linear mixed models (LMMs) has gained popularity because these estimates can be obtained from unrelated individuals collected in genome-wide association studies. Typically, heritability estimation under LMMs uses the restricted maximum likelihood (REML) approach. Existing methods for the constr...

This study aimed to understand how reading ability shapes the lexicality effects on N400. Fifty-three typical developing children from the second to the sixth grades were asked to perform the pronounceability judgment task on a set of Chinese real characters (RC), pseudocharacters (PC) and non-characters (NC), as ERPs were recorded. The cluster-based permutation analysis revealed that children ...