Background: Recurrent nevus is a melanocytic lesion developing at the site of the removal of a previous benign nevus. While most cases are easily diagnosed with traditional histopathologic criteria, some cases have considerable histopathologic overlap with cases of regressed malignant melanoma. Objective: Clinical and histopathologic findings of recurrent nevi are compared to melanoma with regr...

Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic nevi and malignant melanomas, and to investigate the relationship between cyclin expression and some pathological parameters such as tumor thic...

Large congenital melanocytic nevi are cutaneous lesions regarded by many as premalignant; estimates of malignancy incidence range from 0 to 42 percent. Given the often complex and extensive nature of large congenital melanocytic nevi resection and reconstruction, the risk of malignant transformation is a crucial factor that surgeons and families must weigh when deciding whether or not to excise...

Nevus comedonicus is an uncommon variant of adnexal hamartoma and is considered a rare subtype of epidermal nevi. It was first described in 1895 by Kofmann who used the term “comedo-nevus”. It manifests as a group of closely dilated follicular openings with dark keratin plugs resembling comedones. Both unilateral and bilateral distributions are seen. The face is the most commonly affected site ...

M elanocytic nevi, commonly referred to as moles, are very common in children, and the overwhelming majority of melanocytic nevi in children are benign. Given the increased general awareness of melanoma, however, caregivers often express concerns about the development or appearance of their child’s moles. An understanding of the more common types of melanocytic nevi seen in children and of the ...

Monitoring of atypical nevi is an important step in early detection of melanoma, a clinical imperative in preventing the disease progression. Current standard diagnosis is based on biopsy and histopathological examination, a method that is invasive and highly dependent upon the physician’s experience. In this work, we employed a clinical multiphoton microscope to image in vivo and non-invasivel...

Citation: Scope A. Dermatoscopy and Skin Imaging: The section to share your morphological observations and scientific insights. It is a great pleasure and honor to be the Editor of the Der-matoscopy and Skin Imaging Section in Dermatology Practical and Conceptual. We live in very exciting times in clinical dermatology. The use of primary morphology in diagnosis is natural for dermatologists and...

study in Japan. Arch Dermatol. 2004;140(10):1233-1238. 6. Altamura D, Zalaudek I, Sera F, et al. Dermoscopic changes in acral melanocytic nevi during digital follow-up. Arch Dermatol. 2007;143(11):13721376. 7. Ozdemir F, Karaarslan IK, Akalin T. Variations in the dermoscopic features of acquired acral melanocytic nevi. Arch Dermatol. 2007;143(11):13781384. 8. Minagawa A, Koga H, Saida T. Dermos...

Alias: Familial atypical mole-malignant melanoma syndrome (FAMMM); B-K mole syndrome Inheritance: Autosomal dominant with high penetrance and variable expressivity; the frequency of DNS is difficult to evaluate because a number of cases without malignant evolution are not recorded; DNS defines patients with numerous dysplastic nevi. FAMMM defines families where coexist numerous nevi with malign...

A novel automatic method of segmenting nevi is explained and analyzed in this paper. The first step in nevi segmentation is to iteratively apply an adaptive mean shift filter to form clusters in the image and to remove noise. The goal of this step is to remove differences in skin intensity and hairs from the image, while still preserving the shape of nevi present on the skin. Each iteration of ...