In human cells, efficient global genomic repair of DNA damage induced by ultraviolet radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 gene is required for expression of an ultraviolet radiation-damaged DNA binding activity and is disrupted by mutations in the subset of xeroderma pigmentosum group E cells that lack this activity. Here, we show that p48 mRN...

Patients with systemic lupus erythematosus (SLE) have a greatly increased risk of cardiovascular disease. There is growing interest in the link between vascular damage and lupus-specific inflammatory factors. Impaired endothelial repair could account for the endothelial dysfunction in this patient group. This review describes the contribution that endothelial progenitor cells could play in the ...

The emerging field of nanomechanics is providing a new focus in the study of the mechanics of materials, particularly in simulating fundamental atomic mechanisms involved in the initiation and evolution of damage. Simulating fundamental material processes using first principles in physics strongly motivates the formulation of computational multiscale methods to link macroscopic failure to the u...

in this paper, we present a binary-linear optimization model to prevent the spread of an infectious disease in a community. the model is based on the remotion of some connections in a contact network in order to separate infected nodes from the others. by using this model we nd an exact optimal solution and determine not only the minimum number of deleted links but also their exact positions. ...

hemophilia b is factor ix deficiency and is inherited as x-linked recessive disorder. the subject of carrier detection in hemophilias has received new impetus in the last several years. analysis of factor ix gene polymorphisms is considered the best approach for prenatal diagnosis and hemophilia b carrier detection, if the identification of the gene mutation is possible. allele frequencies of t...

seistan was one of the important ancient urban centres in south eastern persia. the ruins of the city show the prosperity and fertility of this city to the extent that a british civil officer considered it as the ancient london of asia. this article attempts to describe the enormous latent wealth of this ancient city which made it important for strategic, political and commercial reasons. due t...

the vertex-edge wiener index of a simple connected graph g is defined as the sum of distances between vertices and edges of g. two possible distances d_1(u,e|g) and d_2(u,e|g) between a vertex u and an edge e of g were considered in the literature and according to them, the corresponding vertex-edge wiener indices w_{ve_1}(g) and w_{ve_2}(g) were introduced. in this paper, we present exact form...

Epigenetic regulation of chromatin and the DNA damage response are now well appreciated key players in human aging. What contributions chromatin and DAN repair make to aging, whether they are causal, and how these relate to other aging pathways, however, is unclear. Novel insights into the aging-related molecular mechanisms that link chromatin and DNA damage repair have recently been gained by ...

Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote tran...

In the framework of the European SCenarios for tsunami Hazard-induced Emergencies MAnagement (SCHEMA) project (www.schemaproject.org), we empirically developed new tsunami damage functions to be used for quantifying the potential tsunami damage to buildings along European-Mediterranean coasts. Since no sufficient post-tsunami observations exist in the Mediterranean areas, we based our work on d...