Endothelium-derived NO controls the contractility and growth state of the underlying vascular smooth muscle cells and regulates the interaction of the vessel wall with circulating blood elements. Acute injury of the vessel wall denudes the endothelial lining, removing homeostatic regulation and precipitating a wave of events leading to myointimal hyperplasia. In this issue of the JCI, Alef and ...

This paper develops a model for the closed-loop supply chain network design with disruption risk. By considering supply disruption, two factors including extra inventory and lateral transshipment are used as resilience strategies. The main purpose is to reduce the supply chain costs due to the location decisions, quantity of products between different levels and lost sale. Disruption in a suppl...

A mobile adhoc network can be defined as a network that is spontaneously deployed and is independent of any static network. The network consists of mobile nodes with wireless interfaces and has an arbitrary dynamic topology. The network suffers from frequent link formation and disruption due to the mobility of the nodes. Distributed algorithms cannot be directly used for the mobile adhoc networ...

Delay/Disruption Tolerant Networking (DTN) “bundles” have been proposed for deep-space communication in the “Interplanetary Internet.” This paper describes the first DTN bundle protocol testing from space, using the United Kingdom Disaster Monitoring Constellation (UK-DMC) satellite in Low Earth Orbit (LEO). The mismatch problems between the different conditions of the private dedicated space-t...

Currently, the RSVP model, which is efficient resource reservation in the fixed endpoints, becomes invalid under host mobility. In this article, we investigate the problems of standard RSVP in providing real-time services in wireless mobile networks. We also observe carefully how to interoperate IntServ services over DiffServ networks, and how to map IntServ QoS parameters into a wireless link....

The appearance of albumin in the urine has long been recognized as a cardinal feature of kidney disease and more recently has been shown to also be an independent cardiovascular risk factor associated with insulin resistance. Recent studies on rare human genetic variants, targeted gene disruption in mouse models and cultured glomerular cells in vitro have dramatically improved our understanding...

in this paper, we consider a cooperative cognitive radio network in which there is an ofdm primary link and multiple single carrier secondary links.the primary link is required to maintain its secrecy rate above a predefined threshold. if the secrecy rate requirement is not satisfied, the secondary system help primary link to maintain its secrecy rate requirement. in doing so, the secondary trans...

in this paper, we present a binary-linear optimization model to prevent the spread of an infectious disease in a community. the model is based on the remotion of some connections in a contact network in order to separate infected nodes from the others. by using this model we nd an exact optimal solution and determine not only the minimum number of deleted links but also their exact positions. ...

hemophilia b is factor ix deficiency and is inherited as x-linked recessive disorder. the subject of carrier detection in hemophilias has received new impetus in the last several years. analysis of factor ix gene polymorphisms is considered the best approach for prenatal diagnosis and hemophilia b carrier detection, if the identification of the gene mutation is possible. allele frequencies of t...

seistan was one of the important ancient urban centres in south eastern persia. the ruins of the city show the prosperity and fertility of this city to the extent that a british civil officer considered it as the ancient london of asia. this article attempts to describe the enormous latent wealth of this ancient city which made it important for strategic, political and commercial reasons. due t...