Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/s...

Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebulization.

conclusions the results indicated that sod-loaded in sln was delivered into deep burned skin layer and induced high enzyme activity through the skin. low particle size, application of lecithin as surfactant and low crystallinity index (ci) percentage were important factors for increasing sod penetration through the burned rat skin. percentage of activity by sln dispersions through rat skin was ...

This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C4F10, C5F12, or C6F14) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs) are of 150 nm average diameter and can be re-imaged for up to an hour after c...