The integration of supported lipid membranes with surface-based nanoplasmonic arrays provides a powerful sensing approach to investigate biointerfacial phenomena at membrane interfaces. While a growing number of lipid vesicles, protein, and nucleic acid systems have been explored with nanoplasmonic sensors, there has been only very limited investigation of the interactions between solution-phas...

this experiment was conducted to evaluate the effect of silver nanoparticles coated on clinoptilolite on performance traits, liver enzymes and blood lipid concentrations to use 375 cobb 500 broiler chickens in completely randomized design with five treatments and five replicates and 15 birds to each replicate. the use of silver nanoparticles coated on clinoptilolite improved feed conversion rat...

Results Uncoated synthesized magnetite nanoparticles and nanoparticles coated by different polysaccharides had no significant effect on synaptic vesicle acidification, the initial velocity of L-[14C]glutamate uptake, ambient level of L-[14C]glutamate and the potential of the plasma membrane of synaptosomes, and conductance of planar lipid membrane. Native ferritin-based magnetic nanoparticles h...

The purpose of this work was to inspect the potential of vincristine-dextran complex loaded solid lipid nanoparticles for drug delivery to the brain. The nanoparticles were stained with a fluorescence dye and their plasma pharmacokinetic and brain concentrations were investigated following injection to rats. The result revealed a significant improvement in the plasma concentration profile of th...

The delivery of drugs and active agents to the skin by formulations containing nanoparticles is a topic of considerable current interest. A number of studies have shown important advantages of these nanostructure-based delivery systems over conventional formulations. This review describes the composition, preparation, and characteristics of a wide range of novel vectors, including nanoemulsions...

Nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs nutrients. Micronutrients nutraceuticals such vitamins, carotenoids, polyunsaturated fatty acids polyphenols are classes food ingredients that essential for human health well-being. These compounds rarely added purely targeted application but rather in encapsulated, solid, dry product fo...

As encapsulation of hydrophilic drugs in the solid lipid nanoparticles (SLNs) is still a challenging issue, the aim of this study was to prepare SLNs containing tramadol hydrochloride as a hydrophilic compound.The SLNs were prepared using glycerol monostearate (GMS), soy lecithin and tween 80 by double emulsification-solvent evaporation technique. The nanoparticles were optimized through a cent...

Lipid-based liquid crystalline nanoparticles (LCNPs) are interesting candidates for drug delivery applications, for instance as solubilizing or encapsulating carriers for intravenous (i.v.) drugs. Here it is important that the carriers are safe and tolerable and do not have, e.g. hemolytic activity. In the present study we have studied LCNP particles of different compositions with respect to th...

The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcei...

The fluorescence interference contrast (FLIC) effect prevents the use of fluorescence techniques to probe the continuity and fluidity of supported lipid bilayers on reflective materials due to a lack of detectable fluorescence. Here we show that adding nanostructures onto reflective surfaces to locally confer a certain distance between the deposited fluorophores and the reflecting surface enabl...