Self-assembling polymeric surfactant, mmePEG(750)P(CL-co-TMC) [monomethylether poly(ethylene glycol)(750)-poly(caprolactone-co-trimethylene carbonate)], increases drug solubility and crosses an enterocyte monolayer both in vitro and in vivo. The aims of the present work were to investigate whether mmePEG(750)P(CL-co-TMC) polymers can diffuse passively through lipid bilayer using parallel artifi...

Neurofibromatosis type 2 (NF2) is a genetic disorder characterized by bilateral schwannomas of the eighth cranial nerve. The NF2 tumor suppressor protein, merlin, is related to the ERM (ezrin, radixin, and moesin) family of membrane/F-actin linkers. Merlin resists solubilization by the detergent Triton X-100 (TX-100), a property commonly attributed to association with the cytoskeleton. Accordin...

(-)-Epigallocatechin gallate (EGCG), a major biologically active constituent of green tea, inhibits activation of the epidermal growth factor (EGF) receptor (EGFR) and downstream signaling pathways in several types of human cancer cells, but the precise mechanism is not known. Because several plasma membrane-associated receptor tyrosine kinases (RTK) including EGFR are localized in detergent-in...

Moderated by Adeline Siew, PhD the oral bioavailability of a drug via several mechanisms, with the unique potential to address both physicochemical and biological obstacles to systemic exposure. It is, therefore, appropriate to describe these mechanisms in relation to the fate of a lipid-based formulation in the gastrointestinal (GI) tract: Stomach. Lipid-based formulations containing the drug,...

Objective: This research aims to optimize the solid lipid nanoparticles by using full factorial design improve delivery of rivastigmine tartrate (RT), which is used for treatment Alzheimer’s disease (AD). Solid (SLNs) are attracting importance drug developers due their performance. The outcome this will lead improvements in release and solubility RT better therapeutic effect. Methods: Four diff...

Lipid-based formulations encompass a diverse group of formulations with very different physical appearance, ranging from simple triglyceride vehicles to more sophisticated formulations such as self-emulsifying drug delivery systems (SEDDS). Lipid-based drug delivery systems may contain a broad range of oils, surfactants, and co-solvents. They represent one of the most popular approaches to over...

The effect of the lipid A moiety of endotoxin on platelet and fibrinogen production was studied in rabbits. Lipid A was infused intravenously in doses ranging from 1 to 100 micrograms/kg body mass; 18 hr later, selenomethionine-75Se was injected intravenously and its incorporation into fibrinogen and platelets determined. Lipid A in saline stimulated fibrinogen and platelet production, but the ...

The extent and site(s) of inhibition of cholesterol absorption by plant sterols, sitosterol and fucosterol, were studied in rats. The intragastric administration of a single emulsified lipid meal containing 25 mg [3H]cholesterol and 25 mg of either sitosterol or fucosterol inhibited the lymphatic absorption of cholesterol by 57% and 41%, respectively, in 24 hr. Less than 2% of each plant sterol...

• Spray-dried camel milk powders were stored at 11–33% RH (37 °C) over 18 weeks. An increase in surface lipid caused an hydrophobicity. Wettability was not affected, and dispersibility solubility dropped during storage. There a strong correlation between content powder solubility. Powder property changes more profound 33% than lower levels. Alterations chemical composition relating to rehydrati...

The Nanostructured Lipid Carriers (NLCs) was formulated with the aim to improve aqueous solubility and thus ultimately oral bioavailability of Axitinib. Axitinib loaded NLCs were using Compritol ATO 888 as solid-lipid, Oleic acid liquid-lipid Tween 80 surfactant by High-Pressure Homogenization technique. A full 23 factorial design utilized study effect independent parameters, solid-lipid ratio ...