BACKGROUND Statin intolerance is a medical condition often leading patients to nonadherence to the prescribed therapy or to a relevant reduction of the statin dosage. Both situations determine a totally or partially uncontrolled lipid profile, and these conditions unquestionably increase the risk of cardiovascular events. METHODS We enrolled hypercholesterolemic, type 2 diabetic patients comp...

Sperm membranes have an unusual lipidic composition which is distinct from those of mammalian somatic cells. They have high levels of plasmalogens, a kind of ether-linked lipids, and a high content of polyunsaturated fatty acyl groups. Plasmalogens may form non-diffusible membrane regions or domains, whereas polyunsaturated ethanolamine plasmalogens are known to destabilize the lipidic bilayer....

Neurodegenerative diseases, in particular Alzheimer disease (AD), afflict an increasing proportion of the older population with aging. Decreased exposure to sunlight and decreased consumption of fish, fruits, and vegetables, are two epidemiological factors that appear to be related to the pandemic of AD. In addition to replacing simple with complex carbohydrates and avoiding saturated fat, two ...

Malaria toxin causes hypoglycemia and induction of tumor necrosis factor. Extracts of parasitized erythrocytes which were coeluted and copurified with one of the two subtypes of mammalian insulin-mimetic inositolphosphoglycans similarly induced fibroblast proliferation in the absence of serum. In addition, induction of tumor necrosis factor in macrophages by malaria toxin and by lipopolysacchar...

Figure 1: (a and b) Magnetic resonance and computed tomography studies display the left ventricle mass, protruding into the pericardial space and infiltrating epicardial fat; 18 months after surgery, a new mass presented with similar characteristics and size. (c) Jelly tumour from the surgeon’s view. (d) Haematoxilin–eosin stain showing a myxoid pattern with a reticulated matrix and elongated c...

J. Anim. Sci. Vol. 88, E-Suppl. 2/J. Dairy Sci. Vol. 93, E-Suppl. 1/Poult. Sci. Vol. 89, E-Suppl. 1 W336 The influence of lipidic sources on the cholesterol plasma levels of beef heifers. M. C. A. Santana*1, T. T. Berchielli1, R. A. Reis1, G. M. P. Melo2, and P. H. M. Dian2, 1São Paulo State University, Jaboticabal, São Paulo, Brazil, 2Camilo Castelo Branco University, Descalvado, São Paulo, Br...