Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imag...

The aim of this review is to outline the recent advances in chitosan molecular modeling, especially its usage as a prodrug or drug in a field of antibacterial, anticarcinogenic and antioxidant activity. Polymeric materials like peptides, polysaccharides and other natural products have recently attracted attention as biodegradabile drug carriers. They can optimize clinical drug application, mini...

In recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. It is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. The aim of this study was to synthesis alginate nanoparticles ...

Purpose: To evaluate effects of liposomes containing the bioactive lipid dilinoleoylphosphatidylcholine (DLPC) on hepatic stellate cells (HSC) activation and liver fibrosis. Methods: To target DLPC-liposomes to HSC, human serum albumin modified with mannose 6-phosphate (M6P-HSA) was coupled to the surface of these liposomes. In vitro, the effects of the carrier were determined in primary cultur...

the most important obligation of the carrier of the goods is to deliver it safe, perfect and well timed to the destination. obviously the loss, missing and delay of the deliver of goods to the destination leads to carrier’s liability. in this paper we examine the calculating method of compensation and its maximum and its exceptions in international contracts that involved of cmr convention. cri...

With the advent of LC-MS, identification and characterization of compounds from plant origin has become very easy now a day. In this effort, several plant-based compounds have been identified possessing therapeutic propensities. This category includes cruciferous vegetables, garlic, ginger, onions, soybeans, and turmeric [1]. Such efforts propel us for large-scale screening of taxonomically aut...

have attracted a lot of interest to develop health and wellness promoting foods and beverages. However, bioactive lipids are water-insoluble and degrade easily during processing and storage, making their addition into foods and beverages challenging. The main objective of this thesis was to develop a novel green process to form bioactive lipid-carrier hollow solid lipid micro-and nanoparticles ...

Nicotinic acetylcholine receptors (AChRs) belong to a superfamily of oligomeric proteins that transduce electric signals across the cell membrane on binding of neurotransmitters. These receptors harbor a large extracellular ligand-binding domain directly linked to an ion-conducting channel-forming domain that spans the cell membrane 20 times and considerably extends into the cytoplasm. Thus far...

Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP-SFX method has recently been introduced in which microcrystals...