Purpose: To search for novel gliomas targets and their inhibitors using a molecular docking approach.
 Methods: Quercetin multi-targeting potential was investigated against some of the emerging such as epidermal growth factor receptor (EGFR), ephrin type-A 2 (EphA2), nicotinamide phosphoribosyltransferase (NMRPTase) plasminogen activator inhibitor-1 (PAI-1). Crucial biochemical inte...

This study presents several new observations from the study of a numerically simulated warm-core ring (WCR) in the Gulf of Mexico based on the ECCO2 global ocean simulation. Using Lagrangian coherent structures (LCS) techniques to investigate this flow reveals a pattern of transversely intersecting LCS in the mixed layer of the WCR which experiences consistent stretching behavior over a large r...

Cyclooxygenase-2 (COX-2) enzyme binds to arachidonic acid and releases metabolites that are used to induce pain and inflammation. COX-2 selective inhibitors such as celecoxib, rofecoxib and valdecoxib are currently used to reduce inflammatory response. However, they lack anti-thrombotic activity and hence lead to cardiovascular and renal liabilities apart from gastrointestinal irritation. There...

Torrefaction is a thermo-chemical process that reduces the moisture content of wood and transforms it into a brittle, char-type material. The thermo-chemical process can reduce the mass of wood by 20-30% resulting in a denser, higher-valued product that can be transported more economically than traditional wood chips. Through torrefaction, wood may retain 90% of the energy value. This energy de...

COVID-19 disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) has struck whole world and raised health, economic, social problems. Many scientists struggled to find a vaccine or an antiviral drug. Eventually, both vaccines recommended drugs, repurposed drug combinations were found, but new strains of SARS-CoV-2 continue threaten human life health. As part fight again...

Recently Nutrition and Food Chemistry researches have been focused on plants and their products or their secondary metabolites having anti-alzheimer, anti-cancer, anti-aging, and antioxidant properties. Among these plants Salvia L. (Lamiaceae) species come into prominence with their booster effects due to high antioxidant contents, which have over 900 species in the world and 98 in Turkey. Some...

Recently Nutrition and Food Chemistry researches have been focused on plants and their products or their secondary metabolites having anti-alzheimer, anti-cancer, anti-aging, and antioxidant properties. Among these plants Salvia L. (Lamiaceae) species come into prominence with their booster effects due to high antioxidant contents, which have over 900 species in the world and 98 in Turkey. Some...

The absence of designated remedies for coronavirus disease 19 (Covid-19) and the lack treatment protocols drove scientists to propose new small molecules attempt repurpose existing drugs against various targets severe acute respiratory syndrome 2 (SARS-CoV-2) in order bring forward efficient solutions. main protease (Mpro) is one most promising drug due its crucial role fighting viral replicati...

Staphylococcus aureus is the most dangerous of all many common staphylococcal bacteria. These gram-positive, sphere-shaped (coccal) bacteria often cause skin infections but can pneumonia, heart valve infections, and bone may be resistant to treatment with some antibiotics. Phenols were abundant phytochemical compounds accounted for 25.8% composition honey. The presence these phytochemicals impl...