Chylomicrons and very low density lipoproteins (VLDL) are produced by the intestine and these nascent particles are thought to be similar to their counterparts in intestinal lymph. To study the relationship between these lipoproteins within the cell and those secreted into the lamina propria and lymph, we have isolated enterocytes, lamina propria, and mesenteric lymph from rats while fasted and...

Dyslipidemia has been associated with premature atherosclerosis and other pathological conditions, and the determination of serum lipids is of great importance in health and disease. Most of the lipids are transported in plasma in the form of lipoproteins. Four classes of lipoproteins have been recognized by electrophoresis: chylomicrons, beta-, pre-beta-, and alpha-lipoproteins. Fredrickson, L...

THE FOLLOWING HUMAN LOW DENSITY LIPOPROTEINS WERE PREPARED: beta-lipoproteins of densities greater than 1.040 (A, B,C) a beta-lipoprotein of -S(1.063) = 5 (D), a lipoprotein of -S(1.063) = 19 (E), and a lipoprotein of -S(1.063) = 70 (F). Data are presented which show the immunochemical homogeneity of the D lipoprotein rabbit-anti-D lipoprotein system. Cross-reactions between antibody to A and D...

The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting ...

Carbon tetralchloride was injected into normnal rabbits and the levels of Sf 3-12, 12-20, alnd(20-40 lasses of lipoproteins were determined during the course of these injections. A marked increase in concentration of these three classes of lipoproteins occurred during the administration of carl)on tetra(hloride. After the cessation of this drug, the lipoproteins of largest Sf rate returned to n...

Among the apoA-I-containing lipoproteins isolated by selected-affinity immunosorption from human serum and plasma, we have identified a subpopulation which, unlike the bulk of high density lipoproteins, has pre-beta electrophoretic mobility. This pre-beta subpopulation can be observed directly in fresh plasma by immunoelectrophoresis. It contains phospholipid and free and esterified cholesterol...

DR. DAVIDSON: Cholesteryl ester transfer protein (CETP) has been a target for the management of risk for cardiovascular disease. This effort began a number of years ago when it was noted that this protein transfers cholesteryl ester in exchange for triglyceride from different lipoproteins, specifically apolipoprotein (apo)B-lipoproteins to high-density lipoproteins (HDL). It’s an exchange that ...

The relationship between the configuration of agarose-gel lipoprotein electrophoresis patterns and the extent of coronary artery disease (CAD) was studied in consecutive patients undergoing diagnostic coronary angiography. Three groups were identified: patients with normal coronary arteries (group 1), patients with minor luminal irregularities (group 2) and patients with significant coronary ar...

A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increased plasma residence time, or that their apolipoprotein E (apoE) content was ab...

The effects of physical exercise and normalization of serum lipoproteins on stress-induced myocardial ischemia were studied in 18 patients with coronary artery disease, stable angina pectoris, and mild hypercholesterolemia (total serum cholesterol 242 +/- 32 mg/dl). These patients underwent a combined regimen of low-fat/low-cholesterol diet and regular, supervised physical exercise at high inte...