During autophagy, a newly formed double membrane surrounds its cargo to generate the so-called autophagosome, which then fuses with a lysosome after closure. Previous work implicated that endosomal Rab7/Ypt7 associates to autophagosomes prior to their fusion with lysosomes. Here, we unravel how the Mon1-Ccz1 guanosine exchange factor (GEF) acting upstream of Ypt7 is specifically recruited to th...

Understanding deuterium fractionation is currently one of the greatest challenges in astrochemistry. In this contribution deuteration experiments of the series CHn , n = 2–5, in a low temperature 22-pole ion trap are used to systematically test a simple chemical rule predicting which molecular ion undergoes deuterium exchange in collisions with HD. CH+4 turns out to be a problem case, where pre...

Autophagy recycles cellular components and defends cells against intracellular pathogens. While viruses must evade autophagocytic destruction, some viruses can also subvert autophagy for their own benefit. The ability of influenza A virus (IAV) to evade autophagy depends on the Matrix 2 (M2) ion-channel protein. We show that the cytoplasmic tail of IAV M2 interacts directly with the essential a...

Mitochondrial autophagy, or mitophagy, is a major mechanism involved in mitochondrial quality control via selectively removing damaged or unwanted mitochondria. Interactions between LC3 and mitophagy receptors such as FUNDC1, which harbors an LC3-interacting region (LIR), are essential for this selective process. However, how mitochondrial stresses are sensed to activate receptor-mediated mitop...

Photoluminescent temperature sensors based on gadolinium orthovanadate (GdVO4) doped with 10% ytterbium and 2% erbium are developed dispersed in different media (lubricant fluid, sol–gel glass, PDMS) to evaluate the best conditions for measurement. Two excitation modes considered: (i) visible by a downshifting (DS) process or (ii) NIR energy transfer upconversion (UC) between Yb Er. The lumines...

Bcl-2-associated athanogen-6 (BAG6) is a nucleocytoplasmic shuttling protein involved in quality control. We previously demonstrated that BAG6 essential for autophagy by regulating the intracellular localization of acetyltransferase EP300, and thus, modifying accessibility to its substrates (TP53 nucleus autophagy-related proteins cytoplasm). Here, we investigated function cytoplasm. First, loc...

This paper discusses the optical spectroscopic properties of the IRAS 1-Jy sample (f60 > 1 Jy) of ultraluminous infrared galaxies (ULIGs: Lir > 10 12 L⊙; Ho = 75 km s −1 Mpc and qo = 0). One hundred and eight of the 118 1-Jy ULIGs have been observed at ∆λ = 8.3 Å resolution over the wavelength range ∼ 4500 Å – 8900 Å. These data are combined with large, previously published sets of optical spec...

We investigate the far-infrared properties of X-ray sources detected in the Chandra Deep Field-South (CDF-S) survey using the ultra-deep 70 μm and 24 μm Spitzer observations taken in this field. Since only 30 (i.e., ≈ 10%) of the 266 X-ray sources in the region of the 70 μm observations are detected at 70 μm, we rely on stacking analyses of the 70 μm data to characterise the average 70 μm prope...