Elias N, Rafii B, Rahman M, Otulakowski G, Cutz E, O’Brodovich H. The role of -, -, and -ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid. Am J Physiol Lung Cell Mol Physiol 293: L537–L545, 2007. First published May 18, 2007; doi:10.1152/ajplung.00373.2006.—Edema fluid (EF) increases epithelial Na transport by rat fetal distal lung epithelia (FDLE) and i...

and Implications When Meishan (M) and Yorkshire (Y) embryos were cotransferred to Y recipients that were then allowed to farrow, it was observed that the birth weights of M and Y littermates were similar averaging 1.15 ± .06 kg. In contrast, placentae matched to M piglets were markedly smaller (.70% lighter) and more vascular (.two-fold) than Y placentae. To investigate the effect of uterine en...

BACKGROUND Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder characterized by uncontrollable dance-like movements, as well as cognitive deficits and mood changes. A feature of HD is a metabolic disturbance that precedes neurological symptoms. In addition, brain cholesterol synthesis is significantly reduced, which could hamper synaptic transmission. OBJECTIVE Alterati...

Type 2 diabetes is a risk factor for Alzheimer’s disease, most likely linked to an impairment of insulin signaling in the brain. The incretin hormone glucagon-like peptide-1 (GLP-1) facilitates insulin signaling, and novel long-lasting GLP-1 analogs, such as liraglutide, are on the market as diabetes therapeutics. GLP-1 has been shown to have neuroprotective properties in vitro and in vivo. Her...

Background The studies on nesting behavior in AD transgenic mice are inconsistent. The aim of this study was to systematically observe nesting behavior of APPswe/PS1dE9 double transgenic mice and their littermate wild-type mice. Methods We chose three age-groups (2-3months,6-8months,10-12months) of male APPswe/PS1dE9 transgenic (Tg) and littermate wild-type (WT) mice to observe their nest-build...

Cryptosporidium spp. cause diarrheal disease worldwide. Innate immune responses mediating resistance to this parasite are not completely understood. To determine whether MyD88-dependent pathways play a role in resistance to Cryptosporidium parvum, we compared the course of infection in MyD88(-/-) mice to that in their wild-type (WT) littermate controls. Three- to 4-week-old mice were infected w...

We have tested the steady-state predictions of the hypothesis that coarctation hypertension, if renin-mediated via total-renal underperfusion, will be characterized by a persistently abnormal renin/bodyfluid-volume relationship. In six inbred Labrador dogs with neonatally-induced thoracic aortic coarctation and in seven littermate controls, serial measurements of forelimb BP, plasma renin activ...

To characterize the secretory patterns of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) during prepubertal development of the gilt, blood samples were collected at 20-min intervals for 4 h once a week from four littermate gilts 10 to 18 wk of age and from another group of four littermate gilts 19 to 25 wk of age. Puberty occurred in the latter group during wk ...

It is generally accepted that cardiac sympathetic tone dominates the control of heart rate (HR) in mice. However, we have recently challenged this notion given that HR in the mouse is responsive to ambient temperature (T(a)) and that the housing T(a) is typically 21-23 degrees C, well below the thermoneutral zone ( approximately 30 degrees C) of this species. To specifically test the hypothesis...

PURPOSE Pathological neovascularization is a crucial component of proliferative retinopathies. Previous studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membrane-anchored metalloproteinase that regulates epidermal growth factor receptor (EGFR) signaling, reduces pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). He...