PURPOSE To characterize changes in relaxation times of liver using quantitative magnetic resonance imaging (MRI) in an experimental mouse model of liver fibrosis. Quantitative MRI is a potentially robust method to characterize liver fibrosis. However, correlation between relaxation times and fibrosis stage has been controversial. MATERIALS AND METHODS Liver fibrosis was induced in male adult ...

INTRODUCTION Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase of IR are not well understood. Objective. The aim was to investigate this question. MATERIAL AND METHODS A rat model of segmental hepatic ischemia was employed. Rats were pre-treated...

Heterozygous mutations of the Hfe gene have been proposed as cofactors in the development and progression of nonalcoholic fatty liver disease (NAFLD). Homozygous Hfe deletion previously has been shown to lead to dysregulated hepatic lipid metabolism and accentuated liver injury in a dietary mouse model of NAFLD We sought to establish whether heterozygous deletion of Hfe is sufficient to promote...

Introduction: Autoimmune hepatitis is an inflammatory liver disorder histologically characterized by portal lymphoplasmocytic with interface activity and lobular inflammation.
 Aims: To identify clinical characteristics associated older age also to pinpoint significant inflammation in histology.
 Methods: Cross-sectional analytical study that evaluated medical records of adult patient...

Objectives: The natural origin of medicinal plants does not guaranteed their safety, as there are no sufficient studies on the safety, efficacy and toxicity to support their beneficial claims. Hence, this study aimed at investigating the oral acute toxicity of Adansonia digitata L. fruit shell extract on mice. Methods: Maceration method was employed for the extraction of Adansonia digitata fru...

For the pathologist, the diagnosis of drug induced liver injury (DILI) is challenging, because histopathological features mimic all primary hepatic and biliary diseases, lacking changes that are specific for DILI. Therefore, in any patient of suspected DILI who underwent liver biopsy, the pathologist will assure the clinician that the observed hepatic changes are compatible with DILI, but this ...

Lipopolysaccharide (LPS) is responsible for causing inflammation leading to septic shock or organ failure. During treatment of infection, high amount of LPS is released in blood circulation due to immediate lysis of bacteria. Since liver helps in clearing LPS from the body, hence it remains the primary target to be stimulated by LPS releasing vigorous amount of inflammatory molecules leading to...

Bile ducts are often analyzed for diagnosis of liver disease, and are an important histopathological structure in liver tissues. We presents an automatic approach to their detection: cell nuclei and other artifacts are detected using a Hough technique; epithelial nuclei are then classified from these objects; inner areas of bile ducts are constructed by iterative voting based on positions of th...