SDF-1alpha/CXCR4 signaling plays a key role in leukemia/bone marrow microenvironment interactions. We previously reported that bone marrow-derived stromal cells inhibit chemotherapy-induced apoptosis in acute myeloid leukemia (AML). Here we demonstrate that the CXCR4 inhibitor AMD3465 antagonized stromal-derived factor 1alpha (SDF-1alpha)-induced and stroma-induced chemotaxis and inhibited SDF-...

UNLABELLED Loss of liver mass and ischemia/reperfusion injury (IRI) are major contributors to postresectional liver failure and small-for-size syndrome. Mesenchymal stromal cell- (MSC-) secreted factors are described to stimulate regeneration after partial hepatectomy. This study investigates if liver-derived MSC-secreted factors also promote liver regeneration after resection in the presence o...

the endometrial stromal nodule is a benign tumor composed of differentiated endometrial stromal cells arranged as a well circumscribed nodule with smooth non-invasive margins. they are rare neoplasms, diagnosed in most instances by microscopy. although nodules are benign in nature, hysterectomy is the treatment of choice to enable evaluation of the tumor margins which are well demarcated in end...

objective(s): endometriosis is a complex gynecologic disease with unknown etiology. noscapine has been introduced as a cancer cell suppressor. endometriosis was considered as a cancer like disorder, the aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells in vitro. materials and methods:in this in vitro study, endometrial biopsie...

background: differentiation, migratory properties and availability of mesenchymal stromal cells (msc) have become an important part of biomedical research. however, the functional heterogeneity of cells derived from different tissues has hampered providing definitive phenotypic markers for these cells. objective: to characterize and compare the phenotype and cytokines of adipose derived mscs (a...

Primary hepatocytes from several different species rapidly lose viability and phenotypic functions on isolation from their native microenvironment of the liver. Stromal cells derived from both within and outside the liver can induce phenotypic functions in primary hepatocytes in vitro; however, the molecular mediators underlying this "coculture effect" have not been fully elucidated. We have pr...

background: bone marrow stromal cells (bmsc) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. however, the transdifferentiation of bmsc into cholinergic phenotype requires more investigation. methods: bmsc were isolated from adult rats, pre-induced with β-mercaptoethanol (bme) and followed by nerve growth factor (ngf) indu...

abstractbackground: fetal bovine serum (fbs) is widely used in cell culture laboratories,risk of zoonotic infections and allergic side effects create obstacles for its use inclinical trials. therefore, an alternative supplement with proper inherent growthpromotingactivities is demanded.objective: to find fbs substitute, we tested human umbilical cord blood serum(hucs) for proliferation of human...

Objective (s): Several methods have been proposed for repairing defects and damages, one of which is cell therapy. Bone marrow stromal cells seem to be suitable for this purpose. On the other hand, many biometric materials are used to improve and correct the defects in the body. Nanofibers are widely used in the medical industry, especially in tissue engineering, as scaffolds in wound healing a...