The effects of local anaesthetics lidocaine, benzocaine, carbisocaine and carbisocaine derivatives, KaQ-7 and Ka-O, in perturbing bovine brain lipid membranes or egg lecithin membranes were compared at pH 6.0; 7.0; and 8.0. The electron spin resonance method with stearic acid labeled at carbon position 16 as the spin probe was employed. The perturbation effects of lidocaine and Ka-O were found ...

Identification, especially of drugs, plays an important role in pharmaceutical analysis. Thin-layer chromatography (TLC) has been widely applied in this field, but sometimes its resolving power leaves something to be desired. Barbiturates, steroids, sulphonamides and local anaesthetics, for example, represent classes where an abundance of closely similar derivatives are available. Separations a...

The contribution of local anaesthetics to dentistry is vast; as almost all the branches in the dental and medical field require them. They are available inmany forms in the current era painless treatment is the at most requirement and the local anesthetics have undergone various advances to provide this painless treatment. This article discusses about the role of two local anesthetic agentslign...