background: the role of estrogen and progesterone in stroke is suggested in previous studies, but yet is controversial. objectives: comparing the plasma levels of estrogen and progesterone and their ratio in ischemic stroke patients and healthy population. materials and methods: this cross-sectional comparative study was conducted from march to september of 2013. sixty-six female patients older...

alzheimer’s disease (ad) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. pelargonidin (pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. this study was designed to assess pel memory enhancing effects on the a rat amyloid beta 25-35 (aβ) intrahippocampal microinjections model of ad in...

There is a strong biological link between the growth hormone (GH) and gonadal systems in growth, development metabolism; however, regulatory interactions are poorly understood. Advances estrogen biology endocrine physiology have provided insights into mechanistic links two systems. Estrogens synthesized from androgens by aromatase which widely distributed extragonadal tissues. Local generation ...

To determine whether mononuclear cell secretory products contribute to the changes in bone turnover that characterize the development of postmenopausal osteoporosis, we evaluated the effects of oophorectomy and subsequent estrogen replacement on the spontaneous secretion of interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) and on the phytohemagglutinin A-induced secretion of gran...

SUMMARY OBJECTIVE: Currently, there is an ongoing debate whether progesterone receptor positive and estrogen negative breast carcinomas represent a true distinct subtype of tumor or mere immunohistochemical artifact. In this study, we conducted immunohistochemistry panel with the antibodies TFF1, EGFR, CK5 to reclassify phenotype in luminal basal-like subtype. METHODS: Tumors -/progesterone +, ...

In postmenopausal breast cancers, locally produced estrogen by adipose stromal cells causes the progression of tumor growth. Although aromatase, a key enzyme of estrogen synthesis, is highly expressed in the adipose stromal cells, and aromatase inhibitors show greater efficacy in postmenopausal breast cancers, the mechanism of increasing aromatase activity in the stromal cells remains unclear. ...

Reduction of ovarian steroids at menopause leads to significant changes in the urogenital tract. These changes often worsen with time, particularly in nonsmokers, affecting up to 38% of menopausal women. Urogenital symptoms that clearly respond to estrogen therapy include atrophic vaginitis, dryness, and accompanying dyspareunia. Estrogen reduces urinary tract infections in women plagued by fre...

It is well established that females mount stronger immune responses than males, but only very little is understood about the underlying mechanisms. We have analyzed local cytokine differences among intact females, those that had been ovariectomized (OVX), those receiving estrogen replacement after OVX, and males, both before and after production of delayed-type hypersensitivity (DTH) responses....