background: magnetic nanoparticles in a variable magnetic field are able to produce heat. this heat (42-45°c) has more selective effect on fast dividing cancer cells than normal tissues. methods: in this work magnetite nanoparticles have been prepared via co-precipitation and phase identification was performed by powder x-ray diffraction (xrd). magnetic parameters of the prepared nanoparticles ...

Platinum rhodamine 123 [Pt(Rh-123)2] was synthesized in an effort to produce a new drug which would have the selective uptake into carcinoma cells of Rh-123 and the alkylating and radiosensitizing properties of the chloroplatinum moiety. Because both Rh-123 and cis-diamminedichloroplatinum(II) (CDDP) have been shown to become more cytotoxic at elevated temperatures, we tested the interactions b...

Platinum rhodamine 123 |1'I(KU-I23)2] was synthesized in an effort to produce a new drug which would have the selective uptake into carcinoma cells of Rh-123 and the alkylating and radiosensitizing properties of the chloroplatinum moiety. Because both Rh-123 and ris-d ¡amminvdichloroplatinum(II) (CDDP) have been shown to become more cytotoxic at elevated temperatures, we tested the interaction...

BACKGROUND Glioblastoma multiforme is the most common and most aggressive malign brain tumor. The 5-year survival rate after tumor resection and adjuvant chemoradiation is only 10 %, with almost all recurrences occurring in the initially treated site. Attempts to improve local control using a higher radiation dose were not successful so that alternative additive treatments are urgently needed. ...

Localized hyperthermia alone can induce regressions in human neoplasms, but superior results can be obtained by integrating hyperthermia with even low doses of radiotherapy. Several clin ical trials demonstrate that hyperthermia plus irradiation can produce higher tumor response rates than the same irradiation alone. While minimal enhancement of irradiation effects on nor mal tissues is reporte...

The safety of weekly regional hyperthermia performed with 8 MHz radiofrequency (RF) capacitive heating equipment has been established in rectal cancer. We aimed to standardize hyperthermia treatment for scientific evaluation and for assessing local tumor response to RF hyperthermia in rectal cancer. Forty-nine patients diagnosed with rectal adenocarcinoma were included in the study. All patient...

The role of microcirculatory factors within and around liver tumors after heat treatment was investigated in a rabbit model of liver cancer (VX2 carcinoma). As a physiological factor of the microenvironment, regional blood flow (RBF) was measured by the hydrogen clearance method, and a histopathological study was done. Local hyperthermia was administered directly to the liver tumor via a 915-MH...

objective: in radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. iododeoxyuridine (iudr) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. improving the potenti...

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications. For instance, Fe3O4 behaves as superparamagnetic as the particle size is reduced to a few nanometers in the single-domain region depending on the type of the material. The superparamagne...

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications. For instance, Fe3O4 behaves as superparamagnetic as the particle size is reduced to a few nanometers in the single-domain region depending on the type of the material. The superparamagne...