Hubs are special centers that used for switching, transferring and handling freight or passengers in transportation systems. The hub location problem deals with locating hub facilities and allocating demand nodes to hubs in order to route the traffic between origin–destination pairs. Aiming at minimizing the total costs, maximizing utilization of transporters, maximizing the service level, etc....

In the literature, hub-networks have often been modeled such as only one mode is considered for all transportation. Also, consolidated demand flows are assumed to be transferred directly between each origin-destination hub pairs. The previous assumptions impose restrictions on practical applications of hub-networks. fact, various transport modes usually retained freight transport, and intermoda...

The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells in the niche environment. Drosophila male germline stem cells (GSCs) attach to somatic hub cells, a component of their niche, through E-cadherin-mediated adherens ...

In portable specially appointed systems (Manets), there is no altered foundation. A standout amongst the most broadly utilized directing conventions for a specially appointed system is the Ad hoc On Demand Distance Vector steering convention, shortened as AODV. In the customary AODV steering convention, source hub advances RREQ (Route Request) bundle to discover way to the terminus hub. The mod...

Although papillary renal cell carcinoma (PRCC) accounts for 10%-15% of renal cell carcinoma (RCC), no predictive molecular biomarker is currently applicable to guiding disease stage of PRCC patients. The mRNASeq data of PRCC and adjacent normal tissue in The Cancer Genome Atlas was analyzed to identify 1148 differentially expressed genes, on which weighted gene co-expression network analysis wa...

Inclement weather at an airline's hub airport can be devastating to that airline's schedule. The repercussions resonate throughout the airline's network as capacity is reduced, connections are missed, and passengers are delayed on a larger scale than during irregular operations at a spoke airport. The main hypothesis behind the work presented in this thesis is that by shifting a small fraction ...

Introduction The Airline Deregulation Act (ADA) of 1978 caused many changes in the industry. For the first time in 40 years, new airlines were permitted to enter the industry, and all airlines could choose the routes they would serve and the fares they would charge. Airlines were also free to exit the industry (go bankrupt), if they made poor choices in these matters. Naturally, this has led to...