نتایج جستجو برای: logp descriptors
تعداد نتایج: 16805 فیلتر نتایج به سال:
Using the sample of long Gamma-ray bursts (GRBs) detected by Swift-BAT before June 2007, we measure the cumulative distribution of the peak photon fluxes (logN–logP ) of the Swift bursts. Compared with the BATSE sample, we find that the two distributions are consistent after correcting the band pass difference, suggesting that the two instruments are sampling the same population of bursts. We a...
The parameters of lipophilicity of spironolactone (a single member of steroids group), which is widely applied as diuretic and antihypertensive agent, were experimentally determined by reversed-phase TLC and HPLC methods as well as calculated using different computer programs and also by a novel mode based on topological indices. Various stationary phases, such as RP-18WFA4254, RP-2F254, RP-18F...
This work quantifies how persistent increases in processor speed compared to I/O speed reduce the performance gap between specialized, high performance messaging layers and general purpose protocols such as TCP/IP and UDP/IP. The comparison is important because specialized layers sacrifice considerable system connectivity and robustness to obtain increased performance. We first quantify the sca...
Kinematics of 237 Chromospherically Active Binaries (CAB) were studied. The sample is heterogeneous with different orbits and physically different components from F to M spectral type main sequence stars to G and K giants and super giants. The computed U , V , W space velocities indicate the sample is also heterogeneous in the velocity space. That is, both kinematically younger and older system...
Introduction: According to mortality rates in Iran, cardiovascular diseases, neoplasms, perinatal mortality, and respiratory tract diseases were top rate mortality in 2003(1382). To reduce mortality rate, Iranian medical community need to know more about recent therapeutic regimens. Two main medical databases are Pubmed and Embase. Researching Pubmed and Embase indexing methods and comparing Me...
mammography has been recognized as the best method of screening for breast cancer, for a long time. although the sensitivity of mammography is acceptable, it has limited specificity and a radiologist should be aware of limitations and pitfalls. there are different positive findings in mammography which are descriptors of breast disease including benign lesions or breast cancer. in this talk i w...
In this paper, the quantitative structure activity-relationship (QSAR) of the CCR2b receptor inhibitors was scrutinized. Firstly, the molecular descriptors were calculated using the Dragon package. Then, the stepwise multiple linear regressions (SW-MLR) and the genetic algorithm multiple linear regressions (GA-MLR) variable selection methods were subsequently employed to select and implement th...
The antibacterial activity of some substituted benzimidazole derivatives against Gram negative bacteria Escherichia coli was investigated. The tested compounds displayed in vitro inhibitory activity and their minimum inhibitory concentrations were determined. Quantitative structure-activity relationship has been used to study the relationships between the antibacterial activity and lipophilicit...
In PRAM emulations, universal hashing is a well-known method for distributing the address space among memory modules. However, if the memory access patterns of an application often result in high module congestion, it is necessary to rehash by choosing another hash function and redistributing data on the fly. For the case of linear hash functions h(x) = axmodm we present an algorithm to rehash ...
The ALOGPS 2.1 was developed to predict 1-octanol/water partition coefficients, logP, and aqueous solubility of neutral compounds. An exclusive feature of this program is its ability to incorporate new user-provided data by means of self-learning properties of Associative Neural Networks. Using this feature, it calculated a similar performance, RMSE = 0.7 and mean average error 0.5, for 2569 ne...
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