Methods:A candidate was chosen based on strict screening criteria including ongoing immunosuppression, proof of compliance and strong family support. The recipient was an eightyear-old quadrimembral amputee secondary to sepsis with distal forearm amputations who was functional with lower extremity prostheses but had failed upper extremity prostheses. A donor was found with ABO compatibility and...

Lower extremity varicose veins are a common condition in vascular surgery and proliferation of vascular smooth muscle cells (VSMCs) in the intima is a significant pathological feature of varicosity. However, the pathogenesis of varicose veins is not fully understood. Osteopontin (OPN) could promote the migration and adhesion of VSMCs through the cell surface receptor integrin β3 and the coopera...

A 32-year-old white man presented to the emergency department after suffering a shotgun wound to the left lower extremity. He reports assault at point-blank range with a gun of unknown gauge while lying in the prone position. He was transported to the emergency department by emergency medical services personnel who started the use of peripherally inserted intravenous catheters and applied press...

Peripheral nerve injuries of the lower extremity (LE) are frequently encountered in orthopaedic practice. They can be traumatic or iatrogenic. Proper and timely diagnosis and treatment are the keys to optimizing outcomes. This paper reviews and discusses the basic anatomy and physiology of nerve injury and the current literature on the incidence, pathogenesis, diagnosis, management and outcomes...

Four neonates suffering from bilateral lower limb gangrene were referred to us for further management. Two neonates had no contributory etiology. All four received appropriate treatment thus avoiding mortality but morbidity could not be avoided. All four neonates recovered uneventfully.

KEY CLINICAL MESSAGE Soft tissue sarcomas are rare tumors accounting for less than 1% of all malignancies. Multidisciplinary approach is used in the management of these patients.

Figure 1. Lower extremity defect status post serial debridement. Exposed hardware can be seen. DESCRIPTION A 39-year-old male with an open wound of the left lower extremity complicated by exposed hardware following open reduction and internal fixation of a tibial plateau fracture.