OBJECTIVE To estimate the accuracy of colposcopy to identify cervical precancer in screening and diagnostic settings. METHODS As part of a larger clinical trial to evaluate the diagnostic accuracy of optical spectroscopy, we recruited 1,850 patients into a diagnostic or a screening group depending on their history of abnormal findings on Papanicolaou tests. Colposcopic examinations were perfo...

Objective: The high number of smear tests has a workload on pathologists/cytopathologists, which raises the concern for quality diagnoses. application high-risk human papillomavirus (hr-HPV) analyses with PAP begun to contribute clinical practice. In this study, we aimed show effect hr-HPV analysis results via atypical squamous cell/squamous intraepithelial lesion (ASC/SIL) ratio standards. Mat...

Background: With the implementation of primary high-risk human papillomavirus (hrHPV) screening in Netherlands, an increase was observed number unnecessary referrals (?Cervical Intraepithelial Neoplasia (CIN) 1) to colposcopy. We aimed investigate which alternative triage strategies safely reduce HPV-based cervical cancer programmes. Methods: Microsimulation model MISCAN used simulate unvaccina...

CONTEXT Persistent infection with high risk human papillomavirus (HPV) has been linked to cervical carcinoma. Integration of viral DNA into host cell DNA is essential for this cancer development, promoting disruption of the HPV E2 gene, thus leading to unregulated increases in E6 and E7 proteins and inactivating the products of p53 and Rb tumor suppressor genes. OBJECTIVE To investigate HPV 1...

BACKGROUND Human Papillomavirus (HPV) infection is known to be associated with a number of conditions including cervical, vaginal, vulvar, penile, anal neoplasias and cancers, oropharynx cancers and genitals warts (GW). Two prophylactic vaccines are currently available: a bivalent vaccine designed to prevent HPV type 16 and 18 infection and a quadrivalent vaccine targeting HPV 6, 11, 16, and 18...

Cervical intraepithelial neoplasms The cervical intraepithelial neoplasms (CINs) are abnormalities of the squamous ectocervical epithelium. The first group consists of squamous intraepithelial lesions of low histological stage (LSIL) and includes flat condyloma and CIN I, while the second group consists of squamous intraepithelial lesions of high histological stage (HSIL) including CIN II and C...

The aim of this study was to determine human papillomavirus (HPV) type distribution in women with and without cervical neoplasia from Asia and to estimate the potential future impact of an HPV 16/18 prophylactic vaccine in this region. A meta-analysis was conducted including 79 studies using polymerase chain reaction to detect HPV types. A total of 5954, 1653, 958, and 16,803 women with invasiv...