Voltage-gated L-type Ca2+ channels (LTCCs) containing a pore-forming alpha1D subunit (D-LTCCs) are expressed in neurons and neuroendocrine cells. Their relative contribution to total L-type Ca2+ currents and their physiological role and significance as a drug target remain unknown. Therefore, we generated D-LTCC deficient mice (alpha1D-/-) that were viable with no major disturbances of glucose ...

Low Temperature Co-fired Ceramic (LTCC) technology is being used for various high frequency applications such as T/R modules for radar, bluetooth communication modules, LAN switches, and automotive radar. One of the key properties of the electronic packages for these applications is microwave loss. LTCC metallizations are typical thick film conductors. Conventional thick film technology has rel...

Gaucher disease is a lysosomal storage disease caused by mutations in acid beta-glucosidase (GCase) leading to defective hydrolysis and accumulation of its substrates. Two L-type calcium channel (LTCC) blockers-verapamil and diltiazem-have been reported to modulate endoplasmic reticulum (ER) folding, trafficking, and activity of GCase in human Gaucher disease fibroblasts. Similarly, these LTCC ...

An innovative method for fabricating the reference cell for a Rubidium (Rb) integrated atomic clock is presented. This method uses low-temperature solder sealing technique for producing mini-cells of the size of 14 x 10 x 3 mm, suitable for Rb miniature atomic clocks. Top and bottom of the cell consists of two glass slides. An LTCC (Low-Temperature Cofired Ceramic) module of 2 mm thickness, equ...

This paper presents the thermal characterization of an LTCC module dedicated for the packaging of a miniature atomic clock. An LTCC device of dimensions of 15 × 22 mm has been designed for the packaging of the elements of a miniature atomic clock. This module acts as a carrier for the components of the clock as well as temperature controller; this is particularly attractive since each component...

An introduction into the subject is given in the context of packaging solutions for sensor applications. Based on a comparison of economical and technical parameters the driving forces to use LTCC are demonstrated. Following these arguments, some actual applications in the field of sensor will be presented outlining in detail the advantages of LTCC and the actual state of the art. This will be ...

L-type calcium channels (Cav1) represent one of the three major classes (Cav1-3) of voltage-gated calcium channels. They were identified as the target of clinically used calcium channel blockers (CCBs; so-called calcium antagonists) and were the first class accessible to biochemical characterization. Four of the 10 known α1 subunits (Cav1.1-Cav1.4) form the pore of L-type calcium channels (LTCC...

A new integration concept for micro-nano-integration based on a new bonding technique between nano-scaled, modified Black Silicon (BSi) and an adapted, unfired LTCC substrate is presented. The novel technique enables to combine advantages of silicon and ceramic technology, especially electrical and fluidic interconnects from nmto mm-scale. Current bonding concepts of silicon on ceramics need jo...

Small therapeutic peptides represent a promising field for the treatment of pathologies such as cardiac diseases. However, the lack of proper target-selective carriers hampers their translation towards a potential clinical application. Aptamers are cell-specific carriers that bind with high affinity to their specific target. However, some limitations on their conjugation to small peptides and t...

In the millimeter-wave band, the series-fed array antenna is facing a problem of large transmission loss and narrow bandwidth by using a high-permittivity and large-loss-tangent material. In this paper, an air region is inserted in the half of the height in the LTCC waveguide of εr =6.6 and tanδ =0.013 to reduce the transmission loss. The reduction of the equivalent dielectric constant by the a...