نتایج جستجو برای: lung fibrosis
تعداد نتایج: 400025 فیلتر نتایج به سال:
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expression is upregulated in response to hypoxia and associated with TGF-β signali...
A number of growth factors and signaling pathways regulate matrix deposition and fibroblast proliferation in the lung. The epidermal growth factor receptor (EGFR) family of receptors and the transforming growth factor-β (TGF-β) family are active in diverse biological processes and are central mediators in the initiation and maintenance of fibrosis in many diseases. Transforming growth factor-α ...
FIZZ (found in inflammatory zone) 1, a member of a cysteine-rich secreted protein family, is highly induced in lung allergic inflammation and bleomycin induced lung fibrosis, and primarily expressed by airway and type II alveolar epithelial cells. This novel mediator is known to stimulate α-smooth muscle actin and collagen expression in lung fibroblasts. The objective of this study was to inves...
Pulmonary veno-occlusive disease (PVOD) is an uncommon in humans and animals caused by pulmonary hypertension (PH). The aim of this study was to investigate pathomorphological findings PVOD a cat. A mass detected the right atrium with echocardiography 11-year-old male Following treatments, necropsy cat performed after death due respiratory failure. Macroscopically, masses were mesenteric lymph ...
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveolar macrophages did not contribute to fibrosis. Using transcriptomic profiling of flow-sorted cell...
Interstitial lung diseases (ILDs) is a wide group of diffuse parenchymal that can lead to interstitial pulmonary fibrosis. Clinical course all ILDs, in particular with chronic fibrosing phenotype, be complicated by an acute exacerbation caused infection. Today, data about clinical COVID-19 patients progressive limited. In this case we described the infection patient pneumonia autoimmune feature...
Diabetes mellitus associated with oxidative stress and inflammation can affect many organs. While the effects of diabetes on organs are well known documented, its mechanisms action lung far less. 
 Hyperglycemia lead to damage by increasing stresses inflammation. may be a trigger for pulmonary fibrosis, as studies suggest that there an important link between fibrosis diabetes. In this revi...
BACKGROUND Single lung transplantation (SLT) is now a treatment option for patients with both pulmonary fibrosis and advanced chronic airway obstruction. Lung function after transplantation might be expected to be different in these two groups of patients because of the effect of the remaining native lung, but the implications of these differences have not been fully explored. METHODS The fun...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of lung parenchyma characterized by a chronic inflammatory cellular infiltration and varying degrees of interstitial fibrosis. Current data indicate that the severity of fibrosis and the degree of cellularity determine, in part, the prognosis of IPF and the response to therapy. Whereas lung biopsy gives the best assessement of fibrosi...
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