CARLICK, DAVID G., AND EUGENE M. RENKIN. Transport of large molecules from plasma to interstitial jluid and lymph in dogs. Am. J. Physiol. 219(6): 1595-1605. 1970-A study was made of the transport of endogenous serum albumin and a graded series of dextrans of 8,000-500,000 mol wt from blood to lymph in the dog’s paw. Sucrose was used as a representative small molecule. Plasma levels of sucrose ...

The purpose of this study was to assess the effects of combined hypoxia and hypercapnia and of severe asphyxia on lung water balance and protein transport in newborn lambs. We studied ten 2-4-wk-old anesthetized lambs which were mechanically ventilated first with air for 2-3 h, then with 10-12% oxygen in nitrogen for 2-4 h, and then with 10-12% oxygen and 10-12% carbon dioxide in nitrogen for 2...

We used plethysmograph techniques to measure or calculate the tissue and capillary forces and flows (capillary pressure, tissue and plasma oncotic pressure, transcapillary pressure drop, lymph flow, and interstitial pressure) in a dog hindpaw preparation in situ at three different venous pressures (PV). Since lymph was flowing from the preparation, an isovolumetric state represented an isofiltr...

OBJECTIVE Lymphatic vessels play an important role in body fluid, as well as immune system homeostasis. Although the role of malfunctioning or missing lymphatics has been studied extensively, less is known on the functional consequences of a chronically expanded lymphatic network or lymphangiogenesis. APPROACH AND RESULTS To this end, we used K14-VEGF-C (keratin-14 vascular endothelial growth...

Exogenous cholesterol, absorbed from the intestinal tract, is transported into the blood by the lymph of the thoracic duct. By means of thoracic duct cannulation and subsequent lymph collection following stomach feeding of 100 mg. of cholesterol dissolved in olive oil, it was found that the nephrotic rat has a diminished rate of cholesterol absorption. This could not be ascribed to a deficiency...