Lymphocyte exit from lymph nodes and their recirculation into blood is controlled by the sphingolipid sphingosine 1-phosphate (S1P). The cellular receptor mediating lymphocyte exit is S1P(1), one of five S1P receptors. Nonselective agonists for S1P receptors lead to blood lymphocyte count reduction. The effects of selective S1P(1) agonists on blood lymphocyte count and their impact in models of...

Background Although neutrophils and lymphocytes play well-established roles in the pathogenesis of Rheumatoid arthritis (RA), their count is most often ignored by clinicians. However, neutrophil/lymphocyte ratio (NLR) seems to be great value evaluation disease activity. Objectives Our objective determine interest this study its relationship with other parameters RA Methods Cross-sectional 70 pa...

INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), C-reactive protein (CRP), ferritin level, CRP-to-albumin (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) non-C...

Various aspects of the immune system display circadian rhythms. Although lymphocyte trafficking has been suggested to show diurnal variations, the mechanisms and influences on immune responses are unclear. Here, we show in mice that inputs from adrenergic nerves contribute to the diurnal variation of lymphocyte recirculation through lymph nodes (LNs), which is reflected in the magnitude of the ...

We have determined the influence of reference particle deformability and suspending buffer tonicity on the measurement of lymphocyte volume by an electronic particle volume analyzer. When the volume analyzer was standardized with latex spherules having a shape factor (f.) of 1 .5. red cell volume was 96 cu m and lymphocyte volume was 289 cu m. The red cell volume corresponded closely to the tru...

This study investigated whether an acute session of high-intensity interval training (HIIT) is sufficient to alter lymphocyte function and redox status. Sixteen young healthy men underwent a HIIT session on a cycloergometer, consisting of eight bouts of 1 min at 90-100% of peak power, with 75 seconds of active recovery at 30 W between bouts. Venous blood was collected before, immediately after,...

BACKGROUND - Older patients are commonly malnourished during hospital stay, and a high prevalence of malnutrition is found in hospitalized patients aged more than 65 years. OBJECTIVE - To investigate whether total lymphocyte count is related to other nutritional markers in hospitalized older adults. METHODS - Hospitalized older adults (N=131) were recruited for a cross-sectional study. Thei...

BACKGROUND Despite advances in the treatment of acute leukemia, many patients need to undergo hematopoietic stem cell transplantation. Recent studies show that early lymphocyte recovery may be a predictor of relapse and survival in these patients. OBJECTIVE To analyze the influence of lymphocyte recovery on Days +30 and +100 post-transplant on the occurrence of relapse and survival. METHODS...