elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. therefore, we made attempts to investigate the protective effect of vitamin e (vit-e), a biological antioxidant in balb/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. several groups of mice were selected and exposed to sub-lethal g -irra...

We have utilized a transendothelial lymphocyte chemotaxis assay to identify and purify a lymphocyte chemoattractant in supernatants of mitogen-stimulated peripheral blood mononuclear cells. Amino acid sequence analysis revealed identity with monocyte chemoattractant protein 1 (MCP-1), a chemoattractant previously thought to be specific for monocytes. Recombinant MCP-1 is chemoattractive for pur...

objective: common variable immunodeficiency (cvid) is one of the most frequent cases of primary immunodeficiency. it is likely that this heterogeneous disease is caused by several distinct genetic disorders. the activation-induced cytidine deaminase (aid) enzyme is involved in class switching, somatic hypermutation (shm) and processes associated with gene conversion in the germinal center. in o...

Objective: To assess the prognostic value of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), and systemic immune-inflammation index (SII) in locally advanced cervical squamous cell carcinoma (LACSC) treated with concurrent chemoradiotherapy (CCRT) regimens. Methods: The contribution immune inflammatory response markers (NLR, PLR, LMR, SII), cell...

The influence of Fe status on cell-mediated immunity was studied in weanling mice fed on Fe-deficient (7 mg Fe/kg), Fe-sufficient (120 mg Fe/kg) and high-Fe (3000 or 5000 mg Fe/kg) diets for 7 weeks. The contact sensitivity (CS) response to dinitrofluorobenzene (DNFB), the in vivo delayed-type hypersensitivity (DTH) response to sheep erythrocytes (SRBC) and the ability of primed spleen cells to...

the objective of the study was to compare the effects of antibiotic virginiamycin, probiotic protexin® and plantago major l. (plantain) on performance, serum metabolites, immune response, and the ileal microbial population of broilers. the experiment was carried out with a total of 200 day-old male ross 308 broiler chickens in a completely randomized design. chickens were allocated to five grou...

conclusions our results demonstrated that r-fla-a could induce cellular and humoral immune response as proper stimulant of poly-isotypic humoral responses. results immunized mice with adjuvanted flagellin showed a considerably increased lymphocyte proliferation compared with the control group (p = 0.004). high level of il-4 and ifn-γ secretion was observed in immunized mice compared with the co...

Objectives: The predictive value of some preoperative inflammatory markers for postoperative infective complications in urinary system stone disease has been demonstrated. We investigated how valuable the systemic immune-inflammation index (SII) is as a marker development response syndrome (SIRS) patients undergoing ureteroscopy. Methods: data 495 who met study criteria were evaluated retrospec...

Objective: Molar pregnancy is the most common type of gestational trophoblastic disease. Gestational disease characterized by lower absolute and relative lymphocyte levels a white blood cell (WBC) count to normal pregnancy. However, no studies have examined WBC missed abortion. The aim this study was investigate whether parameters, such as neutrophil counts, neutrophil-to-lymphocyte ratio (NLR)...

Purpose: Approximately half of rectal cancer cases are diagnosed at a locally advanced stage. It is important to identify biomarkers that can predict pathological complete response in patients undergoing surgery following neoadjuvant chemoradiotherapy.
 Materials and Methods: This retrospective study included 205 with who underwent adjuvant chemotherapy chemoradiotherapy. Inflammatory were...