A concentration of lymphoid tissue is present at the entrance to the respiratory and digestive tracts called Waldeyer's ring. In the oropharynx this takes the form of the pharyngeal tonsils, the lingual tonsils, and scattered lymphoid follicles of the pharyngeal mucosa. This lymphoid tissue functions as a filtering mechanism to prevent deeper spread of infection which has penetrated the mucosal...

Purpose. To report a case of transient lymphoid hyperplasia presenting as bilateral nodular scleral mass in a young male patient. Design. Observational case report. Methods. Chart review. Causes of scleritis were considered and excluded based on detailed history, physical examination, and laboratory investigations. Results. Excisional biopsy of scleral lesions indicated lymphoid tissue. Immunoh...

Several mice with generalized lymphadenopathy were found in the CBA/KlJms (CBA) colony maintained at our institute. A new mutant strain of mice that develop massive lymphoid hyperplasia at 100% incidence within 5 mo after birth was established by crossing these diseased mice. Genetic studies on lymphadenopathy were conducted in F1, F2, and backcross populations from crosses between mutant CBA (...

The incidence of malignant tumors in the primary immunodeficiency diseases is dramatically increased. Four patients with primary immunodeficiencies who developed fatal malignancies are reported. Lymphoreticular tumors and leukemia predominate in most conditions, but epithelial neoplasms are the most common tumors in selective Iga deficiency, and they comprise over one-fourth of malignancies in ...

The c-rel protooncogene encodes a member of the Rel/nuclear factor (NF)-kappaB family of transcriptional factors. To assess the role of the transcriptional activation domain of c-Rel in vivo, we generated mice expressing a truncated c-Rel (Deltac-Rel) that lacks the COOH-terminal region, but retains a functional Rel homology domain. Mice with an homozygous mutation in the c-rel region encoding ...

Cases Case # 1: Girl, 11, afflicts right lower quadrant pain for 3 months. Background Prematurity, atopy (dermatitis, rhinitis, colic). Sister and atopic mother. Physical examination: exquisite tenderness in the right iliac fossa, bilateral Cord colic pain. Dry skin. Laboratori data:all hematology is normal. Examination of normal urine, serial parasitological (-). EDN (eosinophil derived neurot...

A previously healthy 26-year-old woman underwent a routine Papanicolaou test a few weeks after first coitus. As the results suggested atypical squamous cells of uncertain significance, she was referred to a gynecologist. The uterine cervix appeared grossly normal. Microscopic examination of the blind biopsies of the cervix demonstrated diffuse infiltration of atypical large lymphoid cells admix...

A centrofollicular hyperplasia is present within secondary lymphoid organs during all the asymptomatic phase of the HIV disease. Although this hyperplasia has been well characterized by histological studies, the nature of the phenotypic alterations in B cell populations occurring within HIV+ lymphoid organs remains to be established. By immunohistochemistry, we thus investigated whether a parti...