The lifelong infection with the human T lymphotropic virus type 1 (HTLV-1) has been associated a variety of clinical manifestations; one less-explored is HTLV-1-associated pulmonary disease. Imaging lung damage caused by HTLV-1 hyperinflammatory cascade can be similar to sequelae from TB infection. Our study aims describe lesions HTLV-1-positive patients without past or current active and evalu...

The human T-cell lymphotropic virus-1 (HTLV-1) affects worldwide population; the estimated number of currently infected individuals is 10-20 million. In this report, we describe the clinical findings of three family members with vertical transmission of HTLV-1. This case report highlights the importance of healthcare providers who have optimal knowledge about HTLV-1 including its transmission a...

Homologous env sequences from 17 human T-leukemia/lymphotropic virus type I (HTLV-I) strains from throughout the world and from 25 simian T-leukemia/lymphotropic virus type I (STLV-I) strains from 12 simian species in Asia and Africa were analyzed in a phylogenetic context as an approach to resolving the natural history of these related retroviruses. STLV-I exhibited greater overall sequence va...

Screening blood donations for human T-lymphotropic virus types I and II (HTLV-I/II) continues to be important in protecting the safety of blood products and controlling the global spread of these retroviruses. We have developed a fully automated, third generation chemiluminescent immunoassay, ARCHITECT rHTLV-I/II, for detection of antibodies to HTLV-I/II. The assay utilizes recombinant proteins...

Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1]...

1 Equipe Oncogenèse Rétrovirale, CIRI Inserm U1111-CNRS UMR5308, Paris, France 2 Equipe Labellisée “Ligue Nationale Contre le Cancer”, CIRI Inserm U1111-CNRS UMR5308, Paris, France 3 International Center for Research in Infectiology, INSERM U1111 CNRS UMR5308, Paris, France 4 Ecole Normale Supérieure de Lyon, Lyon, France 5 Université Lyon 1, Lyon, France 6 Laboratory of Tumor Cell Biology, Dep...

City-dwelling children from Kenya who were infected with human immunodeficiency virus type 1 (HIV-1) were tested for coinfection with cytomegalovirus (CMV), human T cell lymphotropic viruses 1 and 2, Kaposi sarcoma-associated herpesvirus (KSHV), or hepatitis B, C, and G viruses. All children were found to be coinfected with CMV, whereas 5% had hepatitis G virus coinfection and 15% had KSHV coin...