INTRODUCTION Breast cancer in young women is a relatively rare disease; however it tends to be more aggressive and is the leading cause of cancer death in this population. The aim of this study is to investigate the clinical and biological features of breast cancer arising in young Turkish breast cancer patients. MATERIALS AND METHODS Patients with breast cancer aged 35 or less (≤35 years) we...

OBJECTIVES To determine the associations between serum cancer antigen 15-3 levels and prognostic factors in patients with endometrial carcinomas. Additionally, we investigated the clinical utility of serum cancer antigen 15-3 levels in the selection of low-risk patients with endometrioid type, tumor size less than 2 cm, myometrial invasion ≤50%, and histological grade 1-2. Methods: Ninety-six p...

BACKGROUND Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients. The purpose of this study was to evaluate the correlation between traditional prognostic factors and uPA and PAI-1 expression in primary tumour ...

Pathologic examination of specimens from radical surgery in patients with early-stage cervical cancers provides information that has predictive prognostic potential. Several pathologic features have been extensively studied and recognized as standard prognostic features such as extent of tumor invasion, presence of lymphovascular space invasion (LVSI), parametrial involvement, and lymph node me...

AIM to assess prognostic significance of pathologic features T1 rectal carcinoma in relation regional lymph nodes involvement (N+). MATERIAL AND METHODS : surgical specimens (n = 66) from resection for pT1 were investigated. Following prognosticators evaluated: depth submucosal invasion, grade differentiation, lymphovascular invasion (LVI), tumor budding (Bd), poorly differentiated clusters (PD...

BACKGROUND/AIMS Epithelial-to-mesenchymal transition (EMT) in cancers is related to metastasis, recurrence, and poor prognosis. We evaluated whether EMT-related proteins can act as prognostic biomarkers in colorectal cancer (CRC) patients. METHODS We evaluated the expression of E-cadherin, β-catenin, and S100A4 by immunohistochemistry (IHC) in 333 CRC tissues from the tumor center and invasiv...

Background and Purpose: The frozen section analysis results help determine the appropriate surgery treatment for patients with endometrial adenocarcinoma. This study investigates degree of compliance between final pathology reports in cancer.
 Methods: included 357 adenocarcinoma who underwent operation, follow-up, at our hospital. patients’ demographic, clinical, surgical, pathological da...