Bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces amongst the surfaces of the biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to the biological surface for an extended period of time. Bioadhesive polymeric systems have been used in the development of products for various biomedical applications and surgical glue....

Purpose: The present work describes the development and in vitro and in vivo evaluation of a mucoadhesive nanoparticulate docetaxel (DTX) formulation for intravesical bladder cancer therapy. Experimental Design: Mucoadhesive formulations based on hyperbranched polyglycerols (HPG), hydrophobically derivatized with C8/C10 alkyl chains in the core andmodified withmethoxy-polyethylene glycol (MePEG...

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of verapamil. Frequent administration and variable low bioavailability (40-60%) after oral administration are problems of conventional dosage forms of verapamil can be attenuated by designing it in the form of mucoadhes...

The conventional oral dosage forms have regarding the short duration of delivery to system. A controlled release system designed to increase its residence time in stomach with contact with mucosa was achieved by the formulation of mucoadhesive microsphere of the drug. The aim of the present study is to provide an overview of various aspects of mucoadhesive microsp various polymers, preparation ...

Interaction of the antipsychotic drug risperidone with hydroxypropyl-beta-cyclodextrin (HPBCD) in solution and in the solid state was studied with the aim of overcoming the limitations associated with nasal administration of low solubility drugs. Risperidone solubility studies revealed inclusion complex formation with a 1:1 stoichiometry. Low concentrations (0.1 w/v %) of hydroxypropylmethyl ce...

Purpose: The aim of the present study was to investigate the effect of chitosan molecular weight on size, size distribution, release rate, mucoadhesive properties and electrostatic bonding of alginate/chitosan microparticles containing prednisolone Methods: Three mucoadhesive alginate/chitosan microparticle formulations, f1, f2 and f3, were prepared using low, medium and high chitosan molecular...

A self-propelling colonoscopic device moving inside the colonic tube should be able to periodically grip safely to the colonic wall as well as to manipulate the generated friction. The feasibility of achieving high grip and friction manipulation by covering the device with mucoadhesive films is experimentally tested. More precisely, the frictional behaviour of mucoadhesive films inside the colo...

The aim of study was to prepare and characterize mucoadhesive buccal tablets of glipizide using different Mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K15M in combination. Twenty one formulation were developed with different concentration of mucoadhesive polymers in each formulation.The formulated buccal tablets were tested for surface pH,in vitro drug release and moistu...

Poly(ethylene glycol) (PEG) is widely used in the pharmaceutical, biotechnology, and medical device industries. Although PEG is a biocompatible polymer that has enjoyed widespread use in drug delivery technology, it is not considered adhesive toward mucosal tissue. Here the authors describe a simple approach to enhancing mucoadsorption of PEG polymers through end group functionalization with th...

Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose,...