'UMEROUS CLINICAL TRIALS have been made with : .... lysergide (LSD) in the treatment of alcoholism (1-5). For the most part, the reports of these trials have claimed !_ i_ that lysergide reduces drinking among alcoholics; the percentage of alcoholics stated to be "improved" or "much improved" after _', lysergide has ranged from 50 (5) to 94 (1). A recent critique by _! _ Smart and Storm (6), ho...

BACKGROUND Cryptomarkets are digital platforms that use anonymising software (e.g. Tor) and cryptocurrencies (e.g. Bitcoin) to facilitate trade of goods and services, most notably illicit drugs. Cryptomarkets may reduce systemic violence compared with in-person drug trading because no face-to-face contact is required and disputes can be resolved through a neutral third party. In this paper, we ...

William C. Mullendore took LSD-25 three more times during the next four years, each experience binding him closer in his intellectual apprenticeship to the English-born novelist, lecturer, and philosopher Gerald Heard. Acting as master to novice, Heard introduced Mullendore to LSD as he would later introduce Henry and Clare Boothe Luce and other business leaders, Hollywood celebrities, and arti...

BACKGROUND Epidemiological studies show wide variability in the occurrence of cannabis smoking and related disorders across countries. This study aims to estimate cross-national variation in cannabis users' experience of clinically significant cannabis-related problems in three countries of the Americas, with a focus on cannabis users who may have tried alcohol or tobacco, but who have not used...

OBJECTIVE As there are no studies about the use of ecstasy in Brazil, our aim was to identify the effects and patterns of use of this substance among users in the city of São Paulo. METHODS Subjects were recruited through the snowball technique. Fifty-two subjects of both genders who had been using ecstasy frequently and recently were interviewed. The instrument was a self-reported and anonym...

Psychedelic drugs are a class of compounds that produce a characteristic set of profound and unique changes in human perception, thought, and feeling. There are at least three structurally dissimilar classes of psychedelic drugs: the lysergic acid group, derivatives of tryptamine, and compounds related to phenylethylamine or phenylisopropylamine. Within each of these structural classes, some co...

There is a growing body of evidence supporting the efficacy of various complementary and alternative medicine approaches in the management of headache disorders. These treatment modalities include nutraceutical, physical and behavioral therapies. Nutraceutical options comprise vitamins and supplements (magnesium, riboflavin, coenzyme Q(10), and alpha lipoic acid) and herbal preparations (feverf...