Understanding the role of a given transcription factor (TF) in regulating gene expression requires precise mapping of its binding sites in the genome. Chromatin immunoprecipitation-exo, an emerging technique using λ exonuclease to digest TF unbound DNA after ChIP, is designed to reveal transcription factor binding site (TFBS) boundaries with near-single nucleotide resolution. Although ChIP-exo ...

The goal of this systematic analysis is to provide a comprehensive review of the current cardiac magnetic resonance data on microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH). Data related to the association of MVO and IMH in patients with acute myocardial infarction (MI) with left ventricular (LV) function, volumes, adverse LV remodeling, and major adverse cardiac events (MAC...

Objective: To study the effect of metabolic syndrome (MetSyn) on cardiovascular outcomes after percutaneous coronary intervention (PCI) with bare-metal stents (BMS). Background: The constellation of dyslipidemia, impaired fasting glucose, high blood pressure and abdominal obesity is recognized as MetSyn. MetSyn increases mortality after coronary artery bypass grafting. The influence of MetSyn o...

Current prevention of major adverse cardiovascular events (MACE) after acute coronary syndromes (ACS) is based on aggressive medical therapy, and guideline-driven treatment of traditional coronary risk factors. These include achieving low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, blood pressure, and glycosylated hemoglobin target levels, smoking cessation, and physi...

Atmospheric bromoform at Mace Head, Ireland: Evidence for a peatland source L. J. Carpenter, D. J. Wevill, S. O’Doherty, G. Spain, and P. G. Simmonds Department of Chemistry, University of York, York, YO10 5DD, UK School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK Department of Physics, NUIGalway, Galway, Ireland Received: 21 June 2005 – Accepted: 11 July 2005 – Published: 15 Augu...

OBJECTIVE Patients with Williams syndrome (WS) undergoing cardiac surgery are at risk for major adverse cardiac events (MACE). Prevalence and risk factors for such events have not been well described. We sought to define frequency and risk of MACE in patients with WS using a multicenter clinical registry. METHODS We identified cardiac operations performed in patients with WS using the Society...

OBJECTIVES The aim of this study was to investigate the relationship between intravascular ultrasound (IVUS)-derived measures of atherosclerosis and cardiovascular outcomes. BACKGROUND IVUS has been used in clinical trials to evaluate the effect of medical therapies on coronary atheroma progression. METHODS Coronary plaque progression was evaluated in 4,137 patients in 6 clinical trials tha...

BACKGROUND AND PURPOSE Functional polymorphisms (Ser49Gly and Arg389Gly) in ADRB1 have been associated with cardiovascular and β-blocker response outcomes. Herein we examined associations of these polymorphisms with major adverse cardiovascular events (MACE), with and without stratification by β-blocker treatment in patients with a history of stroke. METHODS Nine hundred and twenty-six partic...

BACKGROUND Silent myocardial infarctions (MIs) are prevalent among diabetic patients and inflict significant morbidity and mortality. Although late gadolinium enhancement (LGE) imaging by cardiac magnetic resonance (CMR) can provide sensitive characterization of myocardial scar, its prognostic significance in diabetic patients without any clinical evidence of MI is unknown. METHODS AND RESULT...

BACKGROUND Although myeloperoxidase (MPO) monitoring is predictive for cardiovascular outcomes in suspected acute coronary syndromes, the value of serial testing is unknown. METHODS We investigated the relationship between serial MPO concentrations in 490 individuals with acute chest pain and incident major adverse cardiac events (MACE) during 6 months of follow-up. We measured MPO with the C...