Telomestatin (TMS: 1) is as a potent and selective telomeric G-quadruplex binder. Two molecules of TMS were suggested to be intercalated to one telomeric G-quadruplex according to docking study. In this paper, we designed and synthesized hexaoxazole TMS derivative (6OTD) dimer, and evaluated its G-quadruplex stabilizing ability.

The use of different metals in Magnetic Resonance Imaging will be briefly described.This overview will be more a qualitative description than a full paper on this topic, in other words, this paper contributes to explaining how and why some metal ions have been chosen for MRI.Paramagnetic compounds are currently used in clinical practice. The main differencesin the four gadolinium complexes come...

In the original publication of the article, a part of Scheme 12 was missed. The correct version of Scheme 12 was provided in this correction article. The original article has also been corrected. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, ...

Novel macrocyclic saccharide receptors that possess terpyridine skeletons as a hydrogen-bonding site are presented. On modification of the hydrogen-bonding sites and the macrocyclic bridges, the receptors showed selective bindings for ribofuranosides, deoxyribofuranosides, and glucopyranosides, respectively. The binding affinities of the receptors were very high, so that native monosaccharides ...

Small-molecule fluorescent probes play a myriad of important roles in chemical sensing. Many such systems incorporating a receptor component designed to recognise and bind a specific analyte, and a reporter or transducer component which signals the binding event with a change in fluorescence output have been developed. Fluorescent probes use a variety of mechanisms to transmit the binding event...

Together, helminth parasites are the most important animal health constraint to global ruminant livestock production. Better control of gastrointestinal and lungworm nematodes (and liver flukes) in Irish and UK cattle is a priority to meet the need for food security through efficient livestock production. Persistent acting macrocyclic lactone anthelmintics are convenient to use and highly effec...

In the title compound, C(24)H(44)N(6) (6+).6C(7)H(7)O(3)S(-).2H(2)O, the macrocycle crystallizes in its hexaprotonated form, accompanied by six p-toluenesulfonate ions and two water molecules, and lies on an inversion center. The three independent p-toluenesulfonate anions and their inversion equivalents at (1 - x, 1 - y, 1 - z) are linked to the macrocyclic cation through N-Hcdots, three dots,...

Two sets of supramolecular rhenium carbonyl-phenanthroline complexes were prepared: fac-[Re(Cl)(CO)(3)(N,N)] and fac-[Re(Etpy)(CO)(3)(N,N)](+), where N,N is 2,9-di-anisyl-1,10-phenanthroline (dap) or two related macrocyclic ligands, where the two anisyl groups are connected by a polyether chain of different length and rigidity (m27, m30), which wraps around and above the equatorial Re(CO)(2) gr...

A new dimension in pincer chemistry: organometallic chemistry of iridium complexes the phosphine-based macrocyclic ligand PNP-14.

A method to ring expand lactams into macrocyclic thiolactones is reported that can be incorporated successive expansion sequences.