The macrocyclic complexes of biological importance with power transition metals are synthesized by template methodology leading to the formation of the complex [MLX] X2; where L is macrocyclic ligand derived from 3,4-diaminotoluene, 2,4-thiazolidinedione, M=Cr (III) and Fe(III) X is Cl-, CH3COO- or NO3_.Characterisation of these complexes are through with the assistance of elemental analyses(CH...

CXCR4 chemokine receptors are found on the surface of immune cells, and together with the specific natural ligand CXCL12 have been revealed to play a role in a number of disease states. For example, the CXCR4CXCL12 signalling system has involvement in cancer progression and metastasis, and the development of rheumatoid arthritis. Also, within the last ten years the CXCR4 and CCR5 co-receptors h...

The macrocyclic nonaaza 3 + 3 amine based on diaminocyclopentane forms enantiopure helical complexes with lanthanide(III) ions. In contrast to analogous complexes based on 1,2-trans-diaminocyclohexane, no clear helicity process is observed. Crystal structures of these compounds show tight helical wrapping of the macrocycle around the lanthanide(III) ion leading to the formation of a double heli...

The three opioid receptors (μ, δ, and κ) are important targets for pain management and have also shown promise as targets for treatment of addiction and mood disorders. In the past, research in the field commonly focused on analysis of structure-activity relationships (SAR) and ligands’ conformational preferences. Recently, advancements permitted determination of crystal structures for each of ...

The precise analysis of redox chemistry of MN4-based macrocyclic complexes is of great importance because of stabilization of unusual oxidation states of metal ions by macrocyclic ligand and thus have various applications in biochemistry, electrochemistry, electrocatalysis, pharmaceuticals etc. In this work, MN4-macrocyclic complexes of Co (II) and Ni(II) transition metal ...

We present a simple and efficient approach to ring-inring nanostructures from readily available starting materials through self-assembly process. The self-assembly tool kit includes divalent dipyridyl ligands, Pd(II) metal ions, and β-cyclodextrin (β-CD). A series of dipyridyl ligands are shown to form inclusion complexes with β-CD in aqueous solution as a result of hydrophobic interactions. On...