نتایج جستجو برای: macrolides

تعداد نتایج: 4269  

Journal: :Pulmonary pharmacology & therapeutics 2010
Akira Tokuda Noriyuki Ohkura Masaki Fujimura Shiho Furusho Miki Abo Nobuyuki Katayama

BACKGROUND Macrolides are antibiotics that have anti-inflammatory activities. Hence, they are used for both acute and chronic inflammatory airway diseases. However, the effects of these agents on allergic airway disorders presenting with an isolated chronic cough, such as non-asthmatic eosinophilic bronchitis and eosinophilic tracheobronchitis with cough hypersensitivity (atopic cough), still r...

Journal: :Tuberculosis 2008
Zhaohai J Zhu Olga Krasnykh Dahua Pan Valentina Petukhova Gengli Yu Yinghui Liu Huiwen Liu Saweon Hong Yuehong Wang Baojie Wan Wenzhong Liang Scott G Franzblau

Existing 14, 15 and 16-membered macrolide antibiotics, while effective for other bacterial infections, including some mycobacteria, have not demonstrated significant efficacy in tuberculosis. Therefore an attempt was made to optimize this class for activity against Mycobacterium tuberculosis through semisyntheses and bioassay. Approximately 300 macrolides were synthesized and screened for anti-...

2012
R. Masekela R. J. Green

Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for the management of bronchiectasis entail antibiotic therapy traditionally used...

2014
Young Ho Seo Jang Su Kim Sung Chul Seo Won Hee Seo Young Yoo Dae Jin Song Ji Tae Choung

PURPOSE The prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) has increased worldwide. The aim of this study was to estimate the proportion of MRMP in a tertiary hospital in Korea, and to find potential laboratory markers that could be used to predict the efficacy of macrolides in children with MRMP pneumonia. METHODS A total of 95 patients with M. pneumoniae pneumonia were enrol...

2016
Max R. Schroeder David S. Stephens

Streptococcus pneumoniae is a common commensal and an opportunistic pathogen. Suspected pneumococcal upper respiratory infections and pneumonia are often treated with macrolide antibiotics. Macrolides are bacteriostatic antibiotics and inhibit protein synthesis by binding to the 50S ribosomal subunit. The widespread use of macrolides is associated with increased macrolide resistance in S. pneum...

Journal: :The Journal of antimicrobial chemotherapy 2002
J Prieto A Calvo M L Gómez-Lus

Antibiotic use has led to increased resistance to certain group markers: penicillin, erythromycin and ciprofloxacin for beta-lactams, macrolides and quinolones, respectively. The influence of resistance to markers in decreasing susceptibility to the drugs included (on the basis of chemical structure) in the corresponding antibiotic group can be defined as 'resistance class effect'. In the case ...

Journal: :American journal of physiology. Lung cellular and molecular physiology 1999
Toshiya Irokawa Tsukasa Sasaki Sanae Shimura Kan Sasamori Takako Oshiro Masayuki Nara Tsutomu Tamada Kunio Shirato

We investigated the acute effects of erythromycin (EM) and its derivatives on ionic currents in airway glands from feline tracheae. Therapeutic concentrations of EM or clarithromycin (CAM) attenuated the whole cell currents evoked by ACh in a competitive manner. The maximally stimulated inward Cl-currents were reduced to 54 and 83% and the outward K+ currents to 55 and 84% of control values by ...

Journal: :Antimicrobial agents and chemotherapy 2006
Satowa Suzuki Tsutomu Yamazaki Mitsuo Narita Norio Okazaki Isao Suzuki Tomoaki Andoh Mayumi Matsuoka Tsuyoshi Kenri Yoshichika Arakawa Tsuguo Sasaki

Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumoniae infection (MR patients) treated with macrolides were compared with those ...

Journal: :The Journal of infectious diseases 2015
Naoki Iwanaga Shigeki Nakamura Kazuhiro Oshima Toshiki Kajihara Takahiro Takazono Taiga Miyazaki Koichi Izumikawa Katsunori Yanagihara Akihiro Sugawara Toshiaki Sunazuka Satoshi Omura Shigeru Kohno

BACKGROUND Streptococcus pneumoniae (pneumococcus) colonizes mucosal surfaces of the upper respiratory tract (URT), resulting in invasive disease. Macrolides are known for their immunomodulatory effects. We investigated the potency of macrolides to reduce pneumococcal colonization by activating host innate immunity. METHODS The kinetics of colonization, cellular response, and inflammatory cyt...

Journal: :The European respiratory journal 2007
M Korppi

REFERENCES 1 Leyten EMS, Prins C, Bossink AWJ, et al. Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-c assay. Eur Respir J 2007; 29: 1212–1216. 2 National Institute for Health and Clinical Excellence. Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control. Clinical Guideline 33. National Institute for C...

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