background: in this work investigation of the normoxic pagat polymer gel dosimeter such as sensitivity, the r2-dose response with post time and the percentage depth dose (pdd) of pagat polymer gel dosimeter have been undertaken. materials and methods: using mri, the formulation to give the maximum change in the transverse relaxation rate r2 was determined to be 4.5% n,n'-methylenbis- acryl...

in this study, we synthesized herceptin conjugated magnetic nanoparticles (hmns) as an alternative probe to discover the levels of her2 (human epidermal growth factor receptor-2) in the surface of cells. these nanoparticles can be used by magnetic resonance imaging (mri) (non-invasive methods) for screening the patients with her2 positive or negative tumors. dextran coated iron oxide nanopartic...

objective multiple sclerosis (ms) is an inflammatory demyelinating disease of central nervous system (cns) that is increasingly being recognized as a disease affecting children. however, the clinical features of childhood ms at onset have been rarely reported from asia. materials & methods this report presents a retrospective chart review of 26 patients with ms (20 females and 6 males), with an...

Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMN...

Magneto-fluorescent nanocomposites of Zn doped ferrites nanoparticles with Pt complexes for magnetic hyperthermia and fluorescent imaging.

concurrent hyperthermia and radiation therapy in treatment of cancer show a strong evidence of a synergistic enhancement. we designed a new self-regulating thermo-brachytherapy seed, which serves as a source of both radiation and heat for concurrent administration of brachytherapy and hyperthermia. the thermo-brachytherapy seed has a core of ferromagnetic material which produces heat when subje...

The present study reports on the preparation and the cell viability assay of two nanoemulsions loaded with magnetic nanoparticle and chloroaluminum phthalocyanine. The preparations contain equal amount of chloroaluminum phthalocyanine (0.05 mg/mL) but different contents of magnetic nanoparticle (0.15 10 or 1.50 10 particle/mL). The human bone marrow mesenchymal stem cell line was used as the mo...

Introduction The human body naturally uses heat to fight disease. For example, viruses and bacteria proliferate at normal body temperatures, so the body instinctively defends itself by increasing its temperature several degrees to slow the rapid multiplication of such disease-causing agents. This phenomenon, commonly called a fever, gives the body an advantage while fighting the infection. Feve...

BACKGROUND Glioblastoma multiforme is the most common and most aggressive malign brain tumor. The 5-year survival rate after tumor resection and adjuvant chemoradiation is only 10 %, with almost all recurrences occurring in the initially treated site. Attempts to improve local control using a higher radiation dose were not successful so that alternative additive treatments are urgently needed. ...

PURPOSE This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose investigation was to test controller's performance and behavior in presence heterogeneous perfusion. MATERIALS AND METHODS Hyperthermia at 42°C induced maintained up 30 min circular section thermometry slice biceps femoris Germa...