Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for targeted therapies. Here, we identify a highly tumorigenic cancer stem cell population in a mouse...

During cerebral cortex development, pyramidal neurons migrate through the intermediate zone and integrate into the cortical plate. These neurons undergo the multipolar-bipolar transition to initiate radial migration. While perturbation of this polarity acquisition leads to cortical malformations, how this process is initiated and regulated is largely unknown. Here we report that the specific up...

Introduction It is recognized that physical and chemical interactions between adjacent ground water and surface water bodies are an important factor impacting water budget and nutrient/ contaminant transport within a watershed (Winter et al., 1998). This observation is also of importance for hazardous waste site cleanup within the United States, since about 75% of sites regulated under the Reso...

Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological and behavioural research. To investigate the behavioural effects of modafinil on anxiety, we admi...

Earth’s mantle transition zone (MTZ) is characterized by several sharp increases in seismic wave speed between ~300 km and ~850 depth. These discontinuities are generally attributed to solid-state phase transitions that lead density viscosity increases, which could cause a barrier convection segregating thermally chemically heterogeneous material. This Review discusses insights into the role of...