Erythrocytic mechanisms involved in malarial infection are poorly understood. We have found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum. Agonists that stimulate cyclic adenosine 3',5'-monophosphate production led to an increase in malarial infe...

LIEUTENANT-COLONEL, I.M.S. Commanding Officer, Indian Military Hospital Nasirabad Owing perhaps to the unsatisfactory results of fumigation and spraying, measures for dealing with the adult mosquito in anti-malarial work have tended to become more defensive than offensive. The War Office report on the health of the army for the year 1931, page 111, under the heading anti-malarial measures reads...

The results obtained by the serological testing of 38 malaria cases are reported in this paper. The indirect fluorescent antibody test (FAT) was used. Plasmodium gallinaceum was used as antigen. Antibodies were detected in 84% of the patients. The results were more satisfactory in cases affected by falciparum malaria. These results suggest that the FAT with P. gallinaceum as antigen can be rega...

background: in the present study, blood serum level of metals were determined in malarial pa­tients and compared with those in the normal subjects without complication using atomic absorp­tion spectrometer. methods: for the determination of these metals twelve intravenous blood samples each from re­ferred malarial patients and a group of normal subjects were collected and immediately centri­fug...

BACKGROUND Former studies have pointed to a monocyte-dependent effect of antibodies in protection against malaria and thereby to cytophilic antibodies IgG1 and IgG3, which trigger monocyte receptors. Field investigations have further documented that a switch from non-cytophilic to cytophilic classes of antimalarial antibodies was associated with protection. The hypothesis that the non-cytophili...

To the Editor of The Indian Medicae Gazette. Sir,?In. the August number of I. M. G. an enquirer ironi Bangalore city wished to know the experiences of medical men in the treatment of pregnant females suffering from malarial fever. Having been placed in this highly malarial station for over four years, and having had to treat more than 30,000 malarial patients including some pregnant females, I ...

Malaria remains a major cause of morbidity and mortality worldwide. The classic presentation of malaria with paroxysms of fever is seen only in 50%–70% of the patients. The development of immunity, the increasing resistance to anti-malarial drugs, and the indiscriminate use of anti-malarial drugs have led to malaria with the presentation of unusual features. Cerebellar ataxia, extrapyramidal ri...

conclusions antipospholipid antibodies based on number of abortions and gestational age of abortions were increased. mean antipospholipid and anticardiolipin antibodies in all patients remained in high level just in first 5 years post abortion and then began to fall. results mean age of participants was 24-39 years old. the average rate of antiphospolipid antibodies in patients with normal anti...

In many Asian populations, the commonest form of severe thalassemia results from the coinheritance of HbE and beta thalassemia. The management of this disease is particularly difficult because of its extreme clinical diversity; although some genetic and adaptive factors have been identified as phenotypic modifiers, the reasons remain unclear. Because the role of the environment in the course of...

BACKGROUND Children in developing countries continue to suffer mortality and morbidity from a number of illnesses, among which are malaria and non-malarial febrile illnesses, which epidemiologically overlap. We examined the spatial pattern and risk factors of co-morbidity of malaria and non-malarial febrile illness among children aged 6-59 months in Nigeria. METHOD Using data from the 2010 Ni...