Abstract Sinonasal malignant melanoma is a rare, aggressive tumor, associated with poor prognosis, accounting for 8-15% of all head and neck melanomas 0.5-2% melanomas. The diagnosis given by histopathological immunological examination. Elective treatment consists surgical excision free resection borders, adjuvant chemotherapy / radiotherapy immunotherapy checkpoint inhibitors can be used to co...

Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in cancer, the prognostic signific...

utaneous foot melanoma is rare; it accounts for approximately 1% of all cutaneous melanoma and can be challenging to manage [1]. There are four main variants of cutaneous malignant melanomas (CMMs), superficial spreading melanoma (SSM), lentigo malignant melanoma (LMM), nodular melanoma (NM) and acral lentiginous melanoma (ALM). Superficial spreading melanoma accounts for approximately 65% of a...

Case Report. A 47-year-old man presented with blurred vision in the right eye. Ophthalmoscopic examination showed several placoid, pigmented lesions in the posterior pole and midperiphery of the retina of both eyes. Results. Patient referred a cutaneous malignant melanoma on the back skin removed 6 years ago. A systemic workup revealed multiple metastases in liver and spleen. After an exhaustiv...

CONTEXT Malignant melanoma commonly metastasizes to the small intestine where it can cause pain, bleeding, and obstruction. However, jaundice from metastatic melanoma is relatively uncommon. CASE REPORT A case of known malignant melanoma presenting as new onset obstructive jaundice as a result of a rarely reported metastasis to the ampulla of Vater. CONCLUSION Multidisciplinary management o...

Incidence Malignant melanoma is the leading cause of death in skin cancers. The incidence of melanoma is reported to vary throughout the world. It demonstrates a clear demographic disparity, and is a common malignancy in Western countries. It is reported at the highest rates in Auckland, New Zealand, with the age-standardized rate of 40.2/100,000 [1]. Other high rates have been reported in Aust...